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Hot Products

Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCN3852	Notoginsenoside Fe
Notoginsenoside Fe can induce gap junction-mediated intercellular communication (GJIC) reductions; and gap junctions have been shown or are believed to be involved in the pathogenesis of many inherited and acquired human diseases, agents that regulate the GJIC function may facilitate prevention and treatment of GJIC-involved diseases.
BCN3853	Notoginsenoside Fc
Notoginsenoside Fc has perfect anti-platelet aggregatory effect.
BCN3854	Notoginsenoside Fa
Notoginsenosides Fa and R4 show significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells.
BCN3855	Alpha-pinene
Alpha-pinene inhibits the nuclear translocation of NF-kappa B induced by LPS in THP-1 cells, and this effect is partly due to the upregulation of I kappa B alpha expression. Alpha-pinene inhibits early root growth and causes oxidative damage in root tissue through enhanced generation of ROS, as indicated by increased lipid peroxidation, disruption of membrane integrity and elevated antioxidant enzyme levels.
BCN3856	Pulegone
Pulegone is a fragrance and flavour ingredient. Pulegone has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. Pulegone induces a verapamil-sensitive psychostimulant effect that appears to independ on the opening of L-type calcium channels.
BCN3857	(-)-beta-Pinene
Important intermed. in manuf. of synthetic aroma compds. Flavouring ingredient.
BCN3858	Kinsenoside
1. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function, it could promote the glucose tolerance of acute glucose increase in both diabetic and normal healthy rats. 2. Kinsenoside shows significant antihepatotoxic activity. 3. Kinsenoside inhibits osteoclastogenesis from macrophages by attenuating RANKL-induced NF-κB and NFATc1 activities, which in turn, prevents bone loss from OVX mice. 4. Kinsenoside can inhibit the production of inflammatory mediators and enhanc anti-inflammatory cytokine generation, therefore, kinsenoside can alleviate acute inflammatory hazards.
BCN8690	Clematichinenoside AR
1. Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties. 2. Clematichinenoside AR has antioxidant and anti-inflammatory cardioprotection effects against MI/R injury, it protects H9c2 cardiomyocytes against H/R-induced apoptosis through mitochondrial-mediated apoptotic signaling pathway. 3. Clematichinenoside AR could be used as an effective neuroprotective agent to protect against ischemic stroke after cerebral I/R injury through regulating both ERK1/2 and cPKC mediated p90RSK/CREB apoptotic pathways. 4. Clematichinenoside AR has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α associated with collagen-induced arthritis.