BCN4387RocaglamideRocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor(CAS NO.:84573-16-0)
BCN4394VasicinoloneBotanical source: The leaves of Adhatoda vasica(CAS NO.:84847-50-7)
BCN6962Sudan IIIBotanical source: The chilli and paprika spice.(CAS NO.:85-86-9)
BCN2085GynuramineBotanical source: The herbs of Gynura japonica(CAS NO.:85611-43-4)
BCN45663-HydroxysarpagineBotanical source: The roots of Rauwolfia serpentina(CAS NO.:857297-90-6)
BCN4408Longistylumphylline ABotanical source: The herbs of Daphniphyllum macropodum(CAS NO.:857672-34-5)
BCN4808AlstolenineBotanical source: The herbs of Alstonia venenata(CAS NO.:85769-33-1)
BCN6903CarbazoleBotanical source: The coal tar.(CAS NO.:86-74-8)
BCN5965CyclovirobuxineCyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction.(CAS NO.:860-79-7)
BCN3512RA VIIBotanical source: The roots of Rubia cordifolia(CAS NO.:86229-97-2)
BCN390610-Hydroxycanthin-6-oneBotanical source: The barks of Picrasma quassioides (D.Don) Benn(CAS NO.:86293-41-6)
BCN2177Dasatinib monohydrateDasatinib monohydrate (BMS-354825 monohydrate) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Ki values of 16 pM and 30 pM for Src and Bcr-Abl, respectively.(CAS NO.:863127-77-9)
BCN2376VinblastineVinblastine is a cytotoxic alkaloid used against various cancer types.(CAS NO.:865-21-4)
BCN3929Gelsempervine ABotanical source: The herbs of Gelsemium elegans(CAS NO.:865187-17-3)
BCN4412N-MethylcalycinineBotanical source: The root of Stephania epigaea(CAS NO.:86537-66-8)
BCN4414Clausine ZBotanical source: The herbs of Clausena excavata(CAS NO.:866111-14-0)
BCN24797-Ethyl-10-HydroxycamptothecinSN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.(CAS NO.:86639-52-3)
BCN4959GramineGramine (Donaxine) is a natural alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties.(CAS NO.:87-52-5)
BCN44165-MethoxystrictamineBotanical source: The herbs of Alstonia scholaris(CAS NO.:870995-64-5)