BCN7838SophorabiosideBotanical source: The seeds of Sophora japonica.(CAS NO.:2945-88-2)
BCN3605EupatoletinBotanical source: The herbs of Eupatorium adenophorum Spreng(CAS NO.:29536-44-5)
BCN8085NegleteinNegletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 and 10.8 μM, respectively.(CAS NO.:29550-13-8)
BCN5199SakuranetinSakuranetin is a rice flavonoid phytoalexin, shows strong antifungal activity. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury.(CAS NO.:2957-21-3)
BCN5326Apigenin-7-glucuronideApigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.(CAS NO.:29741-09-1)
BCN5338Luteolin-7-O-glucuronideLuteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.(CAS NO.:29741-10-4)
BCN2388SilydianinSilydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 17.38 μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products.(CAS NO.:29782-68-1)
BCN5204AstilbinAstilbin, a flavonoid compound, is isolated from the rhizome of Smilax glabra. Astilbin enhances NRF2 activation. Astilbin also suppresses TNF-α expression and NF-κB activation.(CAS NO.:29838-67-3)
BCN5208RobininRobinin is present in flavonoid fraction of Vigna unguiculata leaf. Robinin inhibits upregulated expression of TLR2 and TLR4. Robinin ameliorates oxidized low density lipoprotein (Ox-LDL) induced inflammatory insult through TLR4/NF-κB pathway.(CAS NO.:301-19-9)
BCN4801DalbergioidinBotanical source: The roots of Parochetus communis(CAS NO.:30368-42-4)
BCN6468ToxicarolisoflavoneToxicarol isoflavone is an isoflavone extracted from Millettia brandisiana.(CAS NO.:3044-60-8)
BCN2316Theaflavin-3-gallateTheaflavin-3'-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3'-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3'-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner.(CAS NO.:30462-34-1)
BCN5920Theaflavin 3,3'-di-O-gallateTheaflavin 3,3'-digallate (TF3), the typical pigment in black tea, is a good antitumor agent. Theaflavin 3,3'-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse side effects by affecting multiple signal transduction pathways, such as upregulating p53 and p21, inhibiting phosphorylation of the cell survival protein Akt and MAPK pathway, downregulation of NF-κB, shifting the ratio between pro-/antiapoptotic proteins. Theaflavin 3,3'-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression. Theaflavin 3,3'-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM.(CAS NO.:30462-35-2)
BCN5220MearnsitrinBotanical source: The barks of Clausena excavata(CAS NO.:30484-88-9)
BCN6679LicoricidinLicoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC50=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer. Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect. Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo. Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations.(CAS NO.:30508-27-1)
BCN4784CedeodarinBotanical source: The herbs of Cedrus deodara(CAS NO.:31076-39-8)
BCN5226SideroxylinBotanical source: The leaves of Eucalyptus robusta Smith(CAS NO.:3122-87-0)
BCN5227EucalyptinBotanical source: The branch of Eucalyptus globulus(CAS NO.:3122-88-1)
BCN5232IsobavachinIsobavachin, an antioxidant isaolated from Psoralea morisiana with a prenyl group at position 8 of ring A, promotes neuronal differentiation and the potential role of its protein prenylation.(CAS NO.:31524-62-6)
BCN8071ArtocarpesinBotanical source: The herbs of Cudrania tricuspidata(CAS NO.:3162-09-2)
BCN5237Hesperetin 7-O-glucosideBotanical source: The herb of Mentha aquatica(CAS NO.:31712-49-9)
BCN46525,7-Dihydroxychromone5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells.(CAS NO.:31721-94-5)
