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4',5,6,7-Tetramethoxyflavone

CAS# 1168-42-9

4',5,6,7-Tetramethoxyflavone

2D Structure

Catalog No. BCN8256----Order now to get a substantial discount!

Product Name & Size Price Stock
4',5,6,7-Tetramethoxyflavone: 5mg $615 In Stock
4',5,6,7-Tetramethoxyflavone: 10mg Please Inquire In Stock
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4',5,6,7-Tetramethoxyflavone: 50mg Please Inquire Please Inquire
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4',5,6,7-Tetramethoxyflavone: 200mg Please Inquire Please Inquire
4',5,6,7-Tetramethoxyflavone: 500mg Please Inquire Please Inquire
4',5,6,7-Tetramethoxyflavone: 1000mg Please Inquire Please Inquire

Quality Control of 4',5,6,7-Tetramethoxyflavone

3D structure

Package In Stock

4',5,6,7-Tetramethoxyflavone

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Chemical Properties of 4',5,6,7-Tetramethoxyflavone

Cas No. 1168-42-9 SDF Download SDF
PubChem ID 96118 Appearance Powder
Formula C19H18O6 M.Wt 342.4
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5,6,7-trimethoxy-2-(4-methoxyphenyl)chromen-4-one
SMILES COC1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC)OC)OC
Standard InChIKey URSUMOWUGDXZHU-UHFFFAOYSA-N
Standard InChI InChI=1S/C19H18O6/c1-21-12-7-5-11(6-8-12)14-9-13(20)17-15(25-14)10-16(22-2)18(23-3)19(17)24-4/h5-10H,1-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 4',5,6,7-Tetramethoxyflavone

The roots of Scutellaria baicalensis

Biological Activity of 4',5,6,7-Tetramethoxyflavone

Description1. 4',5,6,7-Tetramethoxyflavone has a hemostatic effect.
TargetsPAFR

4',5,6,7-Tetramethoxyflavone Dilution Calculator

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4',5,6,7-Tetramethoxyflavone Molarity Calculator

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Preparing Stock Solutions of 4',5,6,7-Tetramethoxyflavone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9206 mL 14.6028 mL 29.2056 mL 58.4112 mL 73.014 mL
5 mM 0.5841 mL 2.9206 mL 5.8411 mL 11.6822 mL 14.6028 mL
10 mM 0.2921 mL 1.4603 mL 2.9206 mL 5.8411 mL 7.3014 mL
50 mM 0.0584 mL 0.2921 mL 0.5841 mL 1.1682 mL 1.4603 mL
100 mM 0.0292 mL 0.146 mL 0.2921 mL 0.5841 mL 0.7301 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 4',5,6,7-Tetramethoxyflavone

Effect of Eupatorium odoratum on blood coagulation.[Pubmed:1783877]

J Med Assoc Thai. 1991 May;74(5):283-7.

The purified compound, 4', 5, 6, 7-tetramethoxyflavone, is an active ingredient isolated from Eupatorium odoratum, a Thai indigenous plant that has long been used to stop bleeding. This compound was studied in vitro for the effect on blood clotting factor activities. It was found that the compound enhanced blood coagulation, the observed APTT being shorter than that observed in the control. The result suggested that the compound accelerated clotting time through the intrinsic pathway of the coagulation which may involve the reaction of factor XII, factor XI, factor IX or factor VIII.

Flavonoids from Praxelis clematidea R.M. King and Robinson modulate bacterial drug resistance.[Pubmed:21666549]

Molecules. 2011 Jun 10;16(6):4828-35.

Chemical studies of Praxelis clematidea R.M. King & Robinson resulted in the isolation of six flavones: Apigenine, genkwanine, 7,4'-dimethylapigenin, trimethylapigenin, cirsimaritin and tetramethylscutellarein, which were tested for their toxicity against Staphylococcus aureus SA-1199B, a strain possessing the NorA efflux pump. Efflux pumps are integral proteins of the bacterial membrane and are recognized as one of the main causes of bacterial drug resistance, since they expel antibiotics from the cell. The inhibition of this transporter is one form of modulating bacterial resistance to antimicrobial drugs. The flavones tested did not show any significant antibacterial activity against the Staphylococcus aureus strain used, but were able to modulate bacterial drug resistance. This property might be related to the degree of lipophilicity of the flavones conferred by the methoxyl groups, since 4',5,6,7 tetramethoxyflavone the most methoxylated compound, reduced the minimal inhibitory concentration of the drug 16-fold.

Description

Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive component of Siam weed extract. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) exhibits anti-inflammatory activity through NF-κB pathway. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) modulats of bacterial drug resistance via efflux pump inhibition. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) can enhance blood coagulation.

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