7alpha,15-Dihydroxydehydroabietic acidCAS# 155205-64-4 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 155205-64-4 | SDF | Download SDF |
| PubChem ID | 12047563 | Appearance | Powder |
| Formula | C20H28O4 | M.Wt | 332.43 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1R,4aS,9R,10aR)-9-hydroxy-7-(2-hydroxypropan-2-yl)-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acid | ||
| SMILES | CC12CCCC(C1CC(C3=C2C=CC(=C3)C(C)(C)O)O)(C)C(=O)O | ||
| Standard InChIKey | ALGYTGOYQATWBA-XNFNUYLZSA-N | ||
| Standard InChI | InChI=1S/C20H28O4/c1-18(2,24)12-6-7-14-13(10-12)15(21)11-16-19(14,3)8-5-9-20(16,4)17(22)23/h6-7,10,15-16,21,24H,5,8-9,11H2,1-4H3,(H,22,23)/t15-,16-,19-,20-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 7alpha,15-Dihydroxydehydroabietic acid may exhibit significant cytotoxic activity. |
| Targets | p53 |
7alpha,15-Dihydroxydehydroabietic acid Dilution Calculator
7alpha,15-Dihydroxydehydroabietic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0082 mL | 15.0408 mL | 30.0815 mL | 60.163 mL | 75.2038 mL |
| 5 mM | 0.6016 mL | 3.0082 mL | 6.0163 mL | 12.0326 mL | 15.0408 mL |
| 10 mM | 0.3008 mL | 1.5041 mL | 3.0082 mL | 6.0163 mL | 7.5204 mL |
| 50 mM | 0.0602 mL | 0.3008 mL | 0.6016 mL | 1.2033 mL | 1.5041 mL |
| 100 mM | 0.0301 mL | 0.1504 mL | 0.3008 mL | 0.6016 mL | 0.752 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- 4-(Dimethylamino)cinnamic acid
Catalog No.:BCN5031
CAS No.:1552-96-1
- Cinnamylideneacetic acid
Catalog No.:BCN7777
CAS No.:1552-94-9
- Cordifolioside A
Catalog No.:BCN8224
CAS No.:155179-20-7
- Physapruin A
Catalog No.:BCN7576
CAS No.:155178-03-3
- Plerixafor octahydrobromide
Catalog No.:BCC9123
CAS No.:155148-32-6
- Plerixafor 8HCl (AMD3100 8HCl)
Catalog No.:BCC4447
CAS No.:155148-31-5
- Rosiglitazone maleate
Catalog No.:BCC2262
CAS No.:155141-29-0
- 2-[1-(4-Piperonyl)piperazinyl]benzothiazole
Catalog No.:BCC6771
CAS No.:155106-73-3
- 6-ethyl-3-methyl-4-oxo-4H-pyran-2-carboxylic acid
Catalog No.:BCC8270
CAS No.:1551-49-1
- 11-Deoxyalisol B
Catalog No.:BCN3359
CAS No.:155073-73-7
- 24,25-Dihydroxycycloartan-3-one
Catalog No.:BCN1692
CAS No.:155060-48-3
- SM-21 maleate
Catalog No.:BCC6780
CAS No.:155059-42-0
- Methyl 7,15-dihydroxydehydroabietate
Catalog No.:BCN1693
CAS No.:155205-65-5
- Bimatoprost
Catalog No.:BCC4948
CAS No.:155206-00-1
- Ritonavir
Catalog No.:BCC3620
CAS No.:155213-67-5
- Peraksine
Catalog No.:BCN1694
CAS No.:15527-80-7
- Istradefylline (KW-6002)
Catalog No.:BCC3798
CAS No.:155270-99-8
- NB-598 Maleate
Catalog No.:BCC1788
CAS No.:155294-62-5
- Alisol E 23-acetate
Catalog No.:BCN3459
CAS No.:155301-58-9
- (S)-Sulforaphane
Catalog No.:BCC8097
CAS No.:155320-20-0
- Fluconazole hydrate
Catalog No.:BCC4235
CAS No.:155347-36-7
- p-Menthane-1,3,8-triol
Catalog No.:BCN1695
CAS No.:155348-06-4
- Btk inhibitor 1 R enantiomer hydrochloride
Catalog No.:BCC5126
CAS No.:1553977-42-6
- Ethyl (E)-3'-hydroxy-4'-methoxycinnamate
Catalog No.:BCN3302
CAS No.:155401-23-3
Pinecone of Pinus koraiensis Inducing Apoptosis in Human Lung Cancer Cells by Activating Caspase-3 and its Chemical Constituents.[Pubmed:28027428]
Chem Biodivers. 2017 Apr;14(4).
Pinecones from Pinus koraiensisSiebold & Zucc. (Pinaceae), which have historically been treated as an undesired waste by-product in the processing of seeds, have recently been shown to contain ingredients with potent biological activities, such as polyphenols exhibiting antitumor activity. With this study, we seek to broaden our understanding of antitumor compounds contained in these pinecones beyond just polyphenols. We found that the water extract of P. koraiensis pinecones exhibits significant cytotoxic activity, with IC50 values ranging from 0.62 to 1.73 mg/ml in four human lung cancer cell lines, A549, H1264, H1299, and Calu-6, irrespective of their p53 status. We also demonstrate that pinecone water extract induces apoptosis associated with caspase-3 activation in the same cancer cell lines. Chemical investigation of the pinecone water extract revealed eight main components (1 - 8), and their structures were identified as dehydroabietic acid (1), 15-hydroxy-7-oxodehydroabietic acid (2), 7beta,15-dihydroxydehydroabietic acid (3), beta-d-glucopyranosyl labda-8(17,13)-diene-(15,16)-lactone-19-oate (4), 7alpha,15-Dihydroxydehydroabietic acid (5), (+)-(1S,2S,4R)-limonene-1,2-diol (6), sobrerol (7), and 4-hydroxybenzoic acid (8). These findings suggest a novel biological application of P. koraiensis pinecones in combatting human lung cancer, and further identify the major compounds that could contribute to this anticancer activity.
Two new abietane diterpenoids from the caulis and leaves of Callicarpa kochiana.[Pubmed:21983345]
Fitoterapia. 2012 Jan;83(1):1-5.
Previous studies revealed that diterpenoids from Callicarpa genus were mainly of clerodane-type and phyllocladane-type, and abietane-type diterpenoids were seldom reported. In this paper, we reported two new abietane diterpenoids, kochianic acid A (1) and kochianic acid B (2), together with two known abietane-type diterpenoids, pedunculatic acid B (3) and 7alpha, 15-dihydroxydehydroabietic acid (4), which were all isolated from Callicarpa kochiana. The structures of the new compounds 1 and 2 were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, ROESY and finally confirmed by single-crystal X-ray diffraction.
