Adenanthin

CAS# 111917-59-0

Adenanthin

Catalog No. BCN6000----Order now to get a substantial discount!

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Quality Control of Adenanthin

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Chemical structure

Adenanthin

3D structure

Chemical Properties of Adenanthin

Cas No. 111917-59-0 SDF Download SDF
PubChem ID 15011073 Appearance Powder
Formula C26H34O9 M.Wt 490.6
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1R,2R,4R,6S,8S,9S,10S,11S,13S)-2,8-diacetyloxy-6-hydroxy-5,5,9-trimethyl-14-methylidene-3,15-dioxo-11-tetracyclo[11.2.1.01,10.04,9]hexadecanyl] acetate
SMILES CC(=O)OC1CC2CC3(C1C4(C(CC(C(C4C(=O)C3OC(=O)C)(C)C)O)OC(=O)C)C)C(=O)C2=C
Standard InChIKey WQVYSFSBBFDGRG-FYHXSELJSA-N
Standard InChI InChI=1S/C26H34O9/c1-11-15-8-16(33-12(2)27)20-25(7)18(34-13(3)28)9-17(30)24(5,6)21(25)19(31)23(35-14(4)29)26(20,10-15)22(11)32/h15-18,20-21,23,30H,1,8-10H2,2-7H3/t15-,16+,17+,18+,20+,21-,23+,25+,26+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Adenanthin

The herb of Rabdosia adenantha

Biological Activity of Adenanthin

Description1. Adenanthin has bacteriostatic activity. 2. Adenanthin has antiinflammatory activity. 3. Adenanthin has antitumour activity . 4. Adenanthin is a novel NF-κB and nucleophilic cysteines inhibitor. 5. Adenanthin has antileukemic activity through targeting peroxiredoxin I/II. 6. Adenanthin can serve as the development of Prx I– and Prx II–targeted therapeutic agents.
TargetsNF-kB | ROS | PD-1 | PD-L1

Adenanthin Dilution Calculator

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Adenanthin Molarity Calculator

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Preparing Stock Solutions of Adenanthin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0383 mL 10.1916 mL 20.3832 mL 40.7664 mL 50.958 mL
5 mM 0.4077 mL 2.0383 mL 4.0766 mL 8.1533 mL 10.1916 mL
10 mM 0.2038 mL 1.0192 mL 2.0383 mL 4.0766 mL 5.0958 mL
50 mM 0.0408 mL 0.2038 mL 0.4077 mL 0.8153 mL 1.0192 mL
100 mM 0.0204 mL 0.1019 mL 0.2038 mL 0.4077 mL 0.5096 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Adenanthin

Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells.[Pubmed:22484541]

Nat Chem Biol. 2012 Apr 8;8(5):486-93.

Peroxiredoxins (Prxs) are potential therapeutic targets for major diseases such as cancers. However, isotype-specific inhibitors remain to be developed. We report that Adenanthin, a diterpenoid isolated from the leaves of Rabdosia adenantha, induces differentiation of acute promyelocytic leukemia (APL) cells. We show that Adenanthin directly targets the conserved resolving cysteines of Prx I and Prx II and inhibits their peroxidase activities. Consequently, cellular H(2)O(2) is elevated, leading to the activation of extracellular signal-regulated kinases and increased transcription of CCAAT/enhancer-binding protein beta, which contributes to Adenanthin-induced differentiation. Adenanthin induces APL-like cell differentiation, represses tumor growth in vivo and prolongs the survival of mouse APL models that are sensitive and resistant to retinoic acid. Thus, Adenanthin can serve as what is to our knowledge the first lead natural compound for the development of Prx I- and Prx II-targeted therapeutic agents, which may represent a promising approach to inducing differentiation of APL cells.

Adenanthin targets proteins involved in the regulation of disulphide bonds.[Pubmed:24630929]

Biochem Pharmacol. 2014 May 15;89(2):210-6.

Adenanthin has been recently shown to inhibit the enzymatic activities of peroxiredoxins (Prdx) I and II through its functional alpha,beta-unsaturated ketone group serving as a Michael acceptor. A similar group is found in SK053, a compound recently developed by our group to target the thioredoxin-thioredoxin reductase (Trx-TrxR) system. This work provides evidence that next to Prdx I and II Adenanthin targets additional proteins including thioredoxin-thioredoxin reductase system as well as protein disulfide isomerase (PDI) that contain a characteristic structural motif, referred to as a thioredoxin fold. Adenanthin inhibits the activity of Trx-TR system and PDI in vitro in the insulin reduction assay and decreases the activity of Trx in cultured cells. Moreover, we identified Trx-1 as an Adenanthin binding protein in cells incubated with biotinylated Adenanthin as an affinity probe. The results of our studies indicate that Adenanthin is a mechanism-selective, rather than an enzyme-specific inhibitor of enzymes containing readily accessible, nucleophilic cysteines. This observation might be of importance in considering potential therapeutic applications of Adenanthin to include a range of diseases, where aberrant activity of Prdx, Trx-TrxR and PDI is involved in their pathogenesis.

Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells.[Pubmed:25188510]

Cell Death Dis. 2014 Sep 4;5:e1400.

Adenanthin, a natural diterpenoid isolated from the leaves of Isodon adenanthus, has recently been reported to induce leukemic cell differentiation by targeting peroxiredoxins (Prx) I and II. On the other hand, increasing lines of evidence propose that these Prx proteins would become potential targets to screen drugs for the prevention and treatment of solid tumors. Therefore, it is of significance to explore the potential activities of Adenanthin on solid tumor cells. Here, we demonstrate that Prx I protein is essential for the survival of hepatocellular carcinoma (HCC) cells, and Adenanthin can kill these malignant liver cells in vitro and xenografts. We also show that the cell death-inducing activity of Adenanthin on HCC cells is mediated by the increased reactive oxygen species (ROS) levels. Furthermore, the silencing of Prx I or Prx II significantly enhances the cytotoxic activity of Adenanthin on HCC, whereas the ectopic expression of Prx I and Prx II but not their mutants of Adenanthin-bound cysteines can rescue Adenanthin-induced cytotoxicity in Prxs-silenced HCC cells. Taken together, our results propose that Adenanthin targets Prx I/II to kill HCC cells and its therapeutic significance warrants to be further explored in HCC patients.

Preventive and therapeutic effects of adenanthin on experimental autoimmune encephalomyelitis by inhibiting NF-kappaB signaling.[Pubmed:23964105]

J Immunol. 2013 Sep 1;191(5):2115-25.

Adenanthin, a diterpenoid isolated from the leaves of Isodon adenanthus, has been reported to possess antileukemic activity through targeting peroxiredoxin I/II. However, its other potential activities remain to be explored. Using myelin oligodendrocyte glycoprotein (MOG)35-55-induced experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, we report in this study that Adenanthin exerts efficaciously preventive and therapeutic effects on EAE accompanied by significant restriction of infiltration of inflammatory cells and demyelination in CNS. Adenanthin-presented immunomodulatory effects on EAE are correlated with suppressed proliferation of MOG35-55-reactive T cells, decreased Th1 and Th17 cells, increased regulatory T cell populations, decreased production of serum proinflammatory cytokines, and reduced stimulatory capacity of APCs, which might be mediated by its inhibitory action on NF-kappaB signaling pathway. Our results propose that, as a novel NF-kappaB inhibitor, Adenanthin has potent immunomodulatory activity for the treatment of multiple sclerosis and possibly other autoimmune disorders.

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