MitMAB

CAS# 1119-97-7

MitMAB

2D Structure

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MitMAB: 5mg $35 In Stock
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3D structure

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MitMAB

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Chemical Properties of MitMAB

Cas No. 1119-97-7 SDF Download SDF
PubChem ID 14250 Appearance Powder
Formula C17H38BrN M.Wt 336.39
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO > 10 mM
Chemical Name trimethyl(tetradecyl)azanium;bromide
SMILES CCCCCCCCCCCCCC[N+](C)(C)C.[Br-]
Standard InChIKey CXRFDZFCGOPDTD-UHFFFAOYSA-M
Standard InChI InChI=1S/C17H38N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18(2,3)4;/h5-17H2,1-4H3;1H/q+1;/p-1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of MitMAB

DescriptionDynamin inhibitor; inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50 = 3.1 μM). Targets the dynamin-phospholipid interaction. Inhibits receptor-mediated endocytosis of epidermal growth factor (EGF) in non-neuronal cells; also inhibits synaptic vesicle endocytosis. Displays dynamin I-inhibitory activity similar to OctMAB.

MitMAB Dilution Calculator

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MitMAB Molarity Calculator

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Preparing Stock Solutions of MitMAB

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9727 mL 14.8637 mL 29.7274 mL 59.4548 mL 74.3185 mL
5 mM 0.5945 mL 2.9727 mL 5.9455 mL 11.891 mL 14.8637 mL
10 mM 0.2973 mL 1.4864 mL 2.9727 mL 5.9455 mL 7.4318 mL
50 mM 0.0595 mL 0.2973 mL 0.5945 mL 1.1891 mL 1.4864 mL
100 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.5945 mL 0.7432 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on MitMAB

The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.[Pubmed:20571068]

Mol Cancer Ther. 2010 Jul;9(7):1995-2006.

The endocytic protein dynamin II (dynII) participates in cell cycle progression and has roles in centrosome cohesion and cytokinesis. We have described a series of small-molecule inhibitors of dynamin [myristyl trimethyl ammonium bromides (MitMAB)] that competitively interfere with the ability of dynamin to bind phospholipids and prevent receptor-mediated endocytosis. We now report that dynII functions specifically during the abscission phase of cytokinesis and that MitMABs exclusively block this step in the cell cycle. Cells treated with MitMABs (MitMAB and octadecyltrimethyl ammonium bromide) and dyn-depleted cells remain connected via an intracellular bridge for a prolonged period with an intact midbody ring before membrane regression and binucleate formation. MitMABs are the first compounds reported to exclusively block cytokinesis without affecting progression through any other stage of the cell cycle. Thus, MitMABs represent a new class of antimitotic compounds. We show that MitMABs are potent inhibitors of cancer cell growth and have minimal effect on nontumorigenic fibroblast cells. Thus, MitMABs have toxicity and antiproliferative properties that preferentially target cancer cells. This suggests that dynII may be a novel target for pharmacologic intervention for the treatment of cancer.

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