Arbidol HClAntiviral chemical agent CAS# 131707-23-8 |
Related Products
- CX-4945 (Silmitasertib)
Catalog No.:BCC3693
CAS No.:1009820-21-6
- PA-824
Catalog No.:BCC1106
CAS No.:187235-37-6
- Celastrol
Catalog No.:BCN5986
CAS No.:34157-83-0
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 131707-23-8 | SDF | Download SDF |
| PubChem ID | 9958103 | Appearance | Powder |
| Formula | C22H26BrClN2O3S | M.Wt | 513.88 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Umifenovir hydrochloride | ||
| Solubility | DMSO : 25 mg/mL (48.65 mM; Need ultrasonic) | ||
| Chemical Name | ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate;hydrochloride | ||
| SMILES | CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3.Cl | ||
| Standard InChIKey | OMZHXQXQJGCSKN-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C22H25BrN2O3S.ClH/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;/h6-11,26H,5,12-13H2,1-4H3;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane
IC50 value:
Target: Antiviral; Anti-influenza agent
in vitro: Arbidol was found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with 50% inhibitory concentration (IC50) ranging from 2.7 to 13.8 microg/ml.However, arbidol showed selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5) [1]. Arb interacts with the polar head-group of phospholipid at the membrane interface. Fluorescence studies of interactions between Arb and either tryptophan derivatives or membrane peptides reconstituted into liposomes show that Arb interacts with tryptophan in the micromolar range. Interestingly, apparent binding affinities between lipids and tryptophan residues are comparable with those of Arb IC50 of the hepatitis C virus (HCV) membrane fusion [2]. Arbidol not only prevented the cytopathic effect (CPE) of CVB(5), as demonstrated in an MTT colorimetric assay, when added during or after viral infection, with a 50% inhibitory concentration (IC(50)) from 2.66 to 6.62 microg/ml, but it also decreased the CVB(5)-RNA level in infected host cells, as shown in semi-quantitative RT-PCR [3].
in vivo: Orally administered arbidol at 50 or 100 mg/kg/day beginning 24 h pre-virus exposure for 6 days significantly reduced mean pulmonary virus yields and the rate of mortality in mice infected with FLU-A (A/PR/8/34 H1N1) [1]. BALB/c mice were used as an animal model to test the Arbidol activity in vivo. Orally administered Arbidol at 50 mg/kg body weight/day (once a day) significantly reduced mean virus yields in the lungs and heart as well as mortality after infection for 6 days [3]. References: | |||||
Arbidol HCl Dilution Calculator
Arbidol HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.946 mL | 9.7299 mL | 19.4598 mL | 38.9196 mL | 48.6495 mL |
| 5 mM | 0.3892 mL | 1.946 mL | 3.892 mL | 7.7839 mL | 9.7299 mL |
| 10 mM | 0.1946 mL | 0.973 mL | 1.946 mL | 3.892 mL | 4.8649 mL |
| 50 mM | 0.0389 mL | 0.1946 mL | 0.3892 mL | 0.7784 mL | 0.973 mL |
| 100 mM | 0.0195 mL | 0.0973 mL | 0.1946 mL | 0.3892 mL | 0.4865 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane.
Featured Products
- (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone
Catalog No.:BCC8392
CAS No.:131685-53-5
- Parsonsianine
Catalog No.:BCN2110
CAS No.:131683-36-8
- 8-(1-Chloro-2-hydroxy-3-methylbut-3-enyl)-7-methoxycoumarin
Catalog No.:BCN7058
CAS No.:131652-35-2
- Turmeronol A
Catalog No.:BCN6777
CAS No.:131651-37-1
- Chalepensin
Catalog No.:BCN7334
CAS No.:13164-03-9
- OPC 21268
Catalog No.:BCC7812
CAS No.:131631-89-5
- ACY-241
Catalog No.:BCC6460
CAS No.:1316215-12-9
- Rocilinostat (ACY-1215)
Catalog No.:BCC2144
CAS No.:1316214-52-4
- (+)-Pteryxin
Catalog No.:BCN3470
CAS No.:13161-75-6
- Amyloid Beta-peptide (25-35) (human)
Catalog No.:BCC1027
CAS No.:131602-53-4
- Betulinaldehyde
Catalog No.:BCN1249
CAS No.:13159-28-9
- Calystegine A3
Catalog No.:BCN1884
CAS No.:131580-36-4
New Products
- Urolignoside
Catalog No.:BCN6758
CAS No.:131723-83-6
- Flavopiridol hydrochloride
Catalog No.:BCC3925
CAS No.:131740-09-5
- DAU 5884 hydrochloride
Catalog No.:BCC7263
CAS No.:131780-48-8
- Ugaxanthone
Catalog No.:BCN6775
CAS No.:13179-11-8
- Cardenolide B-1
Catalog No.:BCN4714
CAS No.:1318158-89-2
- Aphagranin A
Catalog No.:BCN6889
CAS No.:1318173-53-3
- (R,R)-2,6-Bis(4-isopropyl-2-oxazolin-2-yl)pyridine
Catalog No.:BCC8396
CAS No.:131864-67-0
- Lexacalcitol
Catalog No.:BCC1704
CAS No.:131875-08-6
- (3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine
Catalog No.:BCC8389
CAS No.:131878-23-4
- 2-Hydroxyethyl Salicylate
Catalog No.:BCN3579
CAS No.:87-28-5
- Fudosteine
Catalog No.:BCC4661
CAS No.:13189-98-5
- Goitrin
Catalog No.:BCN2764
CAS No.:13190-34-6
Umifenovir hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane.
Arbidol HCl,131707-23-8,Umifenovir hydrochloride,Natural Products,Influenza A virus, buy Arbidol HCl , Arbidol HCl supplier , purchase Arbidol HCl , Arbidol HCl cost , Arbidol HCl manufacturer , order Arbidol HCl , high purity Arbidol HCl
