BIBP 3226 trifluoroacetateMixed NPY1-R and NPFF receptor inhibitor CAS# 1068148-47-9 |
- Neuropeptide Y 13-36 (porcine)
Catalog No.:BCC6959
CAS No.:113662-54-7
- BWX 46
Catalog No.:BCC5865
CAS No.:172997-92-1
- BIBO 3304 trifluoroacetate
Catalog No.:BCC7355
CAS No.:191868-14-1
- BIIE 0246
Catalog No.:BCC7158
CAS No.:246146-55-4
- BVD 10
Catalog No.:BCC5882
CAS No.:262418-00-8
- BMS 193885
Catalog No.:BCC7613
CAS No.:679839-66-8
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1068148-47-9 | SDF | Download SDF |
PubChem ID | 56972180 | Appearance | Powder |
Formula | C29H32F3N5O5 | M.Wt | 587.59 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble to 10 mM in sterile water | ||
Chemical Name | (2R)-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid | ||
SMILES | C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O.C(=O)(C(F)(F)F)O | ||
Standard InChIKey | MTSZIDSCWZHKOD-GNAFDRTKSA-N | ||
Standard InChI | InChI=1S/C27H31N5O3.C2HF3O2/c28-27(29)30-17-7-12-23(25(34)31-18-19-13-15-22(33)16-14-19)32-26(35)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21;3-2(4,5)1(6)7/h1-6,8-11,13-16,23-24,33H,7,12,17-18H2,(H,31,34)(H,32,35)(H4,28,29,30);(H,6,7)/t23-;/m1./s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
BIBP 3226 trifluoroacetate Dilution Calculator
BIBP 3226 trifluoroacetate Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.7019 mL | 8.5093 mL | 17.0187 mL | 34.0373 mL | 42.5467 mL |
5 mM | 0.3404 mL | 1.7019 mL | 3.4037 mL | 6.8075 mL | 8.5093 mL |
10 mM | 0.1702 mL | 0.8509 mL | 1.7019 mL | 3.4037 mL | 4.2547 mL |
50 mM | 0.034 mL | 0.1702 mL | 0.3404 mL | 0.6807 mL | 0.8509 mL |
100 mM | 0.017 mL | 0.0851 mL | 0.1702 mL | 0.3404 mL | 0.4255 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
BIBP 3226 trifluoroacetate is a non-peptide neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist with Ki values of 1.1, 79, 108 for rNPY Y1, hNPFF2, rNPFF, respectively.
Neuropeptide Y Y1 receptors (NPY Y1) involve in the regulation of exploratory behaviour and anxiety. Neuropeptide FF (NPFF) is a part of a neurotransmitter system functioning as a modulator of endogenous opioid functions [1].
BIBP 3226 was able to compete for the specific NPFF binding expressed in CHO cells as well as in rat dorsal spinal cord. In hNPFF2 receptors transfected cells, BIBP 3226 (10mM) is able to antagonize the inhibition of forskolin-stimulated cyclic AMP production induced by NPFF (10nM) in a concentration-dependent manner [2].
In male Wistar rats, BIBP3226 at the dose of 5 mg caused an anxiogenic-like effect while the lower dose was ineffective. While, the overall locomotory activity didn’t change in all treatment groups [1]. In mice model, BIBP3226 (5nmol) injected into the third ventricle completely antagonized the hypothermic effects of NPFF (30nmol) and NPVF (30nmol). In the mouse tail-flick assay, BIBP3226 (5nmol) prevented the anti-morphine actions of NPFF (10nmol). Also, in urethane-anaesthetized rats, BIBP3226 (500nmol/kg) significantly reduced the mean arterial blood pressure induced by NPFF (200nmol/kg) and NPVF (200nmol/kg) [3].
References:
[1]. Kask A1, R?go L, Harro J. Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur J Pharmacol, 1996, 317(2-3): R3-4.
[2]. Mollereau C1, Gouardères C, Dumont Y, et al. Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol, 2001, 133(1): 1-4.
[3]. Fang Q1, Guo J, He F, et al. In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides, 2006, 27(9): 2207-2213.
- Diethyl Acetamidomalonate
Catalog No.:BCC2841
CAS No.:1068-90-2
- Otophylloside B
Catalog No.:BCN7267
CAS No.:106758-54-7
- 24-Deacetylalisol O
Catalog No.:BCN3365
CAS No.:1067510-31-9
- GYY 4137 morpholine salt
Catalog No.:BCC7739
CAS No.:106740-09-4
- Olprinone
Catalog No.:BCC1820
CAS No.:106730-54-5
- Boc-D-Lys-OH
Catalog No.:BCC3420
CAS No.:106719-44-2
- Matairesinol 4'-O-beta-gentiobioside
Catalog No.:BCN2848
CAS No.:106647-14-7
- Trachelosiaside
Catalog No.:BCN7743
CAS No.:106647-12-5
- Qingyangshengenin A
Catalog No.:BCN8126
CAS No.:106644-33-1
- 3,10-Dihydroxy-5,11-dielmenthadiene-4,9-dione
Catalog No.:BCN1633
CAS No.:106623-23-8
- Hederacolchiside A1
Catalog No.:BCN6553
CAS No.:106577-39-3
- Parstatin (mouse)
Catalog No.:BCC6042
CAS No.:1065756-01-5
- 5-Allyl-3-methoxy-6-methyl-7-(3,4,5-trimethoxyphenyl)bicyclo[3.2.1]oct-3-ene-2,8-dione
Catalog No.:BCN1632
CAS No.:106894-43-3
- Valproic acid sodium salt (Sodium valproate)
Catalog No.:BCC2156
CAS No.:1069-66-5
- Boc-D-Leucinol
Catalog No.:BCC2723
CAS No.:106930-51-2
- Adefovir
Catalog No.:BCC8808
CAS No.:106941-25-7
- Boc-isoleucinol
Catalog No.:BCC3096
CAS No.:106946-74-1
- Propylamine
Catalog No.:BCN1814
CAS No.:107-10-8
- Taurine
Catalog No.:BCN1750
CAS No.:107-35-7
- Betaine
Catalog No.:BCN6303
CAS No.:107-43-7
- N-Methyltaurine
Catalog No.:BCN1751
CAS No.:107-68-6
- 3-Methyl-1-butylamine
Catalog No.:BCN1810
CAS No.:107-85-7
- H-ß-Ala-OH
Catalog No.:BCC2851
CAS No.:107-95-9
- Sarcosine
Catalog No.:BCN2744
CAS No.:107-97-1