Home >> Research Area >>GPCR/G protein>>NPY Receptors>> BIBP 3226 trifluoroacetate

BIBP 3226 trifluoroacetate

Mixed NPY1-R and NPFF receptor inhibitor CAS# 1068148-47-9

BIBP 3226 trifluoroacetate

Catalog No. BCC7456----Order now to get a substantial discount!

Product Name & Size Price Stock
BIBP 3226 trifluoroacetate: 5mg $805 In Stock
BIBP 3226 trifluoroacetate: 10mg Please Inquire In Stock
BIBP 3226 trifluoroacetate: 20mg Please Inquire Please Inquire
BIBP 3226 trifluoroacetate: 50mg Please Inquire Please Inquire
BIBP 3226 trifluoroacetate: 100mg Please Inquire Please Inquire
BIBP 3226 trifluoroacetate: 200mg Please Inquire Please Inquire
BIBP 3226 trifluoroacetate: 500mg Please Inquire Please Inquire
BIBP 3226 trifluoroacetate: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of BIBP 3226 trifluoroacetate

Number of papers citing our products

Chemical structure

BIBP 3226 trifluoroacetate

3D structure

Chemical Properties of BIBP 3226 trifluoroacetate

Cas No. 1068148-47-9 SDF Download SDF
PubChem ID 56972180 Appearance Powder
Formula C29H32F3N5O5 M.Wt 587.59
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 10 mM in sterile water
Chemical Name (2R)-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O.C(=O)(C(F)(F)F)O
Standard InChIKey MTSZIDSCWZHKOD-GNAFDRTKSA-N
Standard InChI InChI=1S/C27H31N5O3.C2HF3O2/c28-27(29)30-17-7-12-23(25(34)31-18-19-13-15-22(33)16-14-19)32-26(35)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21;3-2(4,5)1(6)7/h1-6,8-11,13-16,23-24,33H,7,12,17-18H2,(H,31,34)(H,32,35)(H4,28,29,30);(H,6,7)/t23-;/m1./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

BIBP 3226 trifluoroacetate Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

BIBP 3226 trifluoroacetate Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of BIBP 3226 trifluoroacetate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7019 mL 8.5093 mL 17.0187 mL 34.0373 mL 42.5467 mL
5 mM 0.3404 mL 1.7019 mL 3.4037 mL 6.8075 mL 8.5093 mL
10 mM 0.1702 mL 0.8509 mL 1.7019 mL 3.4037 mL 4.2547 mL
50 mM 0.034 mL 0.1702 mL 0.3404 mL 0.6807 mL 0.8509 mL
100 mM 0.017 mL 0.0851 mL 0.1702 mL 0.3404 mL 0.4255 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on BIBP 3226 trifluoroacetate

BIBP 3226 trifluoroacetate is a non-peptide neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist with Ki values of 1.1, 79, 108 for rNPY Y1, hNPFF2, rNPFF, respectively.

Neuropeptide Y Y1 receptors (NPY Y1) involve in the regulation of exploratory behaviour and anxiety. Neuropeptide FF (NPFF) is a part of a neurotransmitter system functioning as a modulator of endogenous opioid functions [1].

BIBP 3226 was able to compete for the specific NPFF binding expressed in CHO cells as well as in rat dorsal spinal cord. In hNPFF2 receptors transfected cells, BIBP 3226 (10mM) is able to antagonize the inhibition of forskolin-stimulated cyclic AMP production induced by NPFF (10nM) in a concentration-dependent manner [2].

In male Wistar rats, BIBP3226 at the dose of 5 mg caused an anxiogenic-like effect while the lower dose was ineffective. While, the overall locomotory activity didn’t change in all treatment groups [1]. In mice model, BIBP3226 (5nmol) injected into the third ventricle completely antagonized the hypothermic effects of NPFF (30nmol) and NPVF (30nmol). In the mouse tail-flick assay, BIBP3226 (5nmol) prevented the anti-morphine actions of NPFF (10nmol). Also, in urethane-anaesthetized rats, BIBP3226 (500nmol/kg) significantly reduced the mean arterial blood pressure induced by NPFF (200nmol/kg) and NPVF (200nmol/kg) [3].

References:
[1].  Kask A1, R?go L, Harro J. Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur J Pharmacol, 1996, 317(2-3): R3-4.
[2].  Mollereau C1, Gouardères C, Dumont Y, et al. Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol, 2001, 133(1): 1-4.
[3].  Fang Q1, Guo J, He F, et al. In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides, 2006, 27(9): 2207-2213.

Featured Products
New Products
 

Description

BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect.

Keywords:

BIBP 3226 trifluoroacetate,1068148-47-9,Natural Products,NPY Receptors, buy BIBP 3226 trifluoroacetate , BIBP 3226 trifluoroacetate supplier , purchase BIBP 3226 trifluoroacetate , BIBP 3226 trifluoroacetate cost , BIBP 3226 trifluoroacetate manufacturer , order BIBP 3226 trifluoroacetate , high purity BIBP 3226 trifluoroacetate

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: