CurcumenoneCAS# 100347-96-4 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 100347-96-4 | SDF | Download SDF |
| PubChem ID | 153845 | Appearance | Powder |
| Formula | C15H22O2 | M.Wt | 234.3 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1R,6S,7R)-6-methyl-7-(3-oxobutyl)-3-propan-2-ylidenebicyclo[4.1.0]heptan-4-one | ||
| SMILES | CC(=C1CC2C(C2(CC1=O)C)CCC(=O)C)C | ||
| Standard InChIKey | HUZJLWLCLJEXEL-NFAWXSAZSA-N | ||
| Standard InChI | InChI=1S/C15H22O2/c1-9(2)11-7-13-12(6-5-10(3)16)15(13,4)8-14(11)17/h12-13H,5-8H2,1-4H3/t12-,13-,15+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Curcumenone may have protective effect on drunkenness, through increasing liver alcohol dehydrogenase activity. |
Curcumenone Dilution Calculator
Curcumenone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.268 mL | 21.3402 mL | 42.6803 mL | 85.3606 mL | 106.7008 mL |
| 5 mM | 0.8536 mL | 4.268 mL | 8.5361 mL | 17.0721 mL | 21.3402 mL |
| 10 mM | 0.4268 mL | 2.134 mL | 4.268 mL | 8.5361 mL | 10.6701 mL |
| 50 mM | 0.0854 mL | 0.4268 mL | 0.8536 mL | 1.7072 mL | 2.134 mL |
| 100 mM | 0.0427 mL | 0.2134 mL | 0.4268 mL | 0.8536 mL | 1.067 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- L(+)-Rhamnose monohydrate
Catalog No.:BCN8368
CAS No.:10030-85-0
- Pemirolast potassium
Catalog No.:BCC4532
CAS No.:100299-08-9
- Apiopaeonoside
Catalog No.:BCN2801
CAS No.:100291-86-9
- Irinotecan hydrochloride
Catalog No.:BCN2949
CAS No.:100286-90-6
- TZ9
Catalog No.:BCC5547
CAS No.:1002789-86-7
- Picrasidine J
Catalog No.:BCN5820
CAS No.:100234-62-6
- Picrasidine I
Catalog No.:BCN5819
CAS No.:100234-59-1
- AMG-208
Catalog No.:BCC1054
CAS No.:1002304-34-8
- Camstatin
Catalog No.:BCC5690
CAS No.:1002295-95-5
- 5,5'-Dimethoxysecoisolariciresinol
Catalog No.:BCN7941
CAS No.:1002106-91-3
- 2,3-dihydroxy-3-(4-hydroxyphenyl)propanoic acid
Catalog No.:BCN1641
CAS No.:100201-57-8
- Piscidinol A
Catalog No.:BCN5818
CAS No.:100198-09-2
- Calcium chloride dihydrate
Catalog No.:BCC7582
CAS No.:10035-04-8
- GSK 1562590 hydrochloride
Catalog No.:BCC8010
CAS No.:1003878-07-6
- Sodium Picosulfate
Catalog No.:BCC4845
CAS No.:10040-45-6
- Danshinspiroketallactone
Catalog No.:BCN3754
CAS No.:100414-80-0
- Lercanidipine
Catalog No.:BCC5239
CAS No.:100427-26-7
- Boric acid
Catalog No.:BCC7592
CAS No.:10043-35-3
- Cobicistat (GS-9350)
Catalog No.:BCC2271
CAS No.:1004316-88-4
- Dihydroresveratrol 3-O-glucoside
Catalog No.:BCN5821
CAS No.:100432-87-9
- 1-EBIO
Catalog No.:BCC6904
CAS No.:10045-45-1
- FFN 511
Catalog No.:BCC7799
CAS No.:1004548-96-2
- Rosiridin
Catalog No.:BCN5970
CAS No.:100462-37-1
- Gastrin I (human)
Catalog No.:BCC5958
CAS No.:10047-33-3
Effects of the extracts and an active compound curcumenone isolated from Curcuma zedoaria rhizomes on alcohol-induced drunkenness in mice.[Pubmed:23160092]
Fitoterapia. 2013 Jan;84:163-9.
The Curcuma zedoaria rhizome has been used traditionally to treat gastrointestinal diseases as an aromatic stomachic drug, and this is currently used to treat alcohol-induced loss of appetite and nausea in Japan. We examined the effects of various fractions and isolated compounds on alcohol-induced drunkenness and blood alcohol concentrations in mice. The 30% ethanol-extract (1000mg/kg) of C. zedoaria rhizome prevented drunkenness 60 and 120min after 40% alcohol administration. The n-hexane-soluble fraction (300mg/kg) and an isolated compound (3, 10 or 30mg/kg) prevented drunkenness at 30, 60 or 120min. The extract, n-hexane-soluble fraction and isolated compound reduced the elevation in blood alcohol concentrations 30 and 60min after 40% alcohol administration. The isolated compound (10 and 30mg/kg) enhanced liver ADH activity 30 and 60min after 40% alcohol administration. The compound was identified as Curcumenone by a direct comparison of (1)H- and (13)C-NMR spectral data. In conclusion, the protective effect of the C. zedoaria extract on drunkenness might be due to an active substance, Curcumenone, and decreases in the elevation of blood alcohol concentrations through increased liver alcohol dehydrogenase activity.
Spectrofluorometric and molecular docking studies on the binding of curcumenol and curcumenone to human serum albumin.[Pubmed:25756376]
Int J Mol Sci. 2015 Mar 6;16(3):5180-93.
Curcumenol and Curcumenone are two major constituents of the plants of medicinally important genus of Curcuma, and often govern the pharmacological effect of these plant extracts. These two compounds, isolated from C. zedoaria rhizomes were studied for their binding to human serum albumin (HSA) using the fluorescence quench titration method. Molecular docking was also performed to get a more detailed insight into their interaction with HSA at the binding site. Additions of these sesquiterpenes to HSA produced significant fluorescence quenching and blue shifts in the emission spectra of HSA. Analysis of the fluorescence data pointed toward moderate binding affinity between the ligands and HSA, with Curcumenone showing a relatively higher binding constant (2.46 x 105 M-1) in comparison to curcumenol (1.97 x 104 M-1). Cluster analyses revealed that site I is the preferred binding site for both molecules with a minimum binding energy of -6.77 kcal.mol-1. However, binding of these two molecules to site II cannot be ruled out as the binding energies were found to be -5.72 and -5.74 kcal.mol-1 for curcumenol and Curcumenone, respectively. The interactions of both ligands with HSA involved hydrophobic interactions as well as hydrogen bonding.
