DC_AC50

Selective Atox1 and CCS inhibitor CAS# 497061-48-0

DC_AC50

Catalog No. BCC6488----Order now to get a substantial discount!

Product Name & Size Price Stock
DC_AC50: 5mg $391 In Stock
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Chemical structure

DC_AC50

3D structure

Chemical Properties of DC_AC50

Cas No. 497061-48-0 SDF Download SDF
PubChem ID 1025330 Appearance Powder
Formula C17H12BrF2N3OS M.Wt 424.26
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO
SMILES C1CC2=C(C1)N=C3C(=C2)C(=C(S3)C(=O)NC4=C(C=C(C=C4Br)F)F)N
Standard InChIKey DFNOJNBNTVQPCA-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H12BrF2N3OS/c18-10-5-8(19)6-11(20)14(10)23-16(24)15-13(21)9-4-7-2-1-3-12(7)22-17(9)25-15/h4-6H,1-3,21H2,(H,23,24)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

DC_AC50 Dilution Calculator

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DC_AC50 Molarity Calculator

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Preparing Stock Solutions of DC_AC50

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.357 mL 11.7852 mL 23.5705 mL 47.1409 mL 58.9261 mL
5 mM 0.4714 mL 2.357 mL 4.7141 mL 9.4282 mL 11.7852 mL
10 mM 0.2357 mL 1.1785 mL 2.357 mL 4.7141 mL 5.8926 mL
50 mM 0.0471 mL 0.2357 mL 0.4714 mL 0.9428 mL 1.1785 mL
100 mM 0.0236 mL 0.1179 mL 0.2357 mL 0.4714 mL 0.5893 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on DC_AC50

DC_AC50 is a selective inhibitor of human copper-trafficking proteins Atox1 and CCS with Kd values of ∼6.8 μM and ∼8.2 μM [1].

Human copper-trafficking proteins Atox1 and CCS are cytosolic copper chaperones that transfer

copper to specific cellular destinations [1].

DC_AC50 is a selective inhibitor of human copper-trafficking proteins Atox1 and CCS. DC_AC50 is a self-fluorescing compound with excitations at 290 nm and 355 nm, and emission at 494 nm. In FRET assay, DC_AC50 bound to Atox1 and full-length CCS with Kd values of ∼6.8 μM and 8.2 μM. In fluorescence anisotropy (FA) assay, DC_AC50 bound to Atox1, full-length CCS and CCS domain I with Kd values of 6.4 μM, 7.9 μM and 12.2 μM. In human lung cancer H1299 cells, leukaemia cancer K562 cells, breast cancer MDA-MB-231 cells and head and neck cancer 212LN cells, DC_AC50 dose-dependently inhibited cancer cell proliferation by targeting Atox1 and CCS. DC_AC50 also induced reactive oxygen species (ROS) accumulation, reduced cellular ATP production and decreases lipid biosynthesis via AMP-activated protein kinase (AMPK) activation [1].

In nude mice bearing lung cancer H1299 cells or leukaemia cancer K562 cells, DC_AC50 (100 mg/kg per day for 21 days) significantly decreased tumour size compared with vehicle control. In K562 mice model, DC_AC50 (10, 20 and 50 mg/kg per day) also induced a similar tumor-inhibition effects without any obvious toxicity or a change in body weight [1].

Reference:
[1].  Wang J, Luo C, Shan CL, et al. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nature Chemistry, 2015, published online 09 November 2015.

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