Evodine

CAS# 6989-38-4

Evodine

Catalog No. BCN2630----Order now to get a substantial discount!

Product Name & Size Price Stock
Evodine: 5mg $288 In Stock
Evodine: 10mg Please Inquire In Stock
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Quality Control of Evodine

Number of papers citing our products

Chemical structure

Evodine

3D structure

Chemical Properties of Evodine

Cas No. 6989-38-4 SDF Download SDF
PubChem ID 398789 Appearance Powder
Formula C18H19NO5 M.Wt 329.35
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1-(4,8-dimethoxyfuro[2,3-b]quinolin-7-yl)oxy-3-methylbut-3-en-2-ol
SMILES CC(=C)C(COC1=C(C2=C(C=C1)C(=C3C=COC3=N2)OC)OC)O
Standard InChIKey LNJTUUHDKCPQAA-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H19NO5/c1-10(2)13(20)9-24-14-6-5-11-15(17(14)22-4)19-18-12(7-8-23-18)16(11)21-3/h5-8,13,20H,1,9H2,2-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Evodine

The fruits of Evodia rutaecarpa

Biological Activity of Evodine

DescriptionEvodine may have antinociceptive activity.
In vivo

Antinociceptive activity of aqueous and alcohol extract of evodia rutaecarpa.[Pubmed: 25035536]

Indian J Pharm Sci. 2014 May;76(3):235-9.

Water, methanol and ethanol extracts of Evodia rutaecarpa were tested for antinociceptive activity, which were correlated with the contents of evodiamine, rutaecarpine and Evodine.
METHODS AND RESULTS:
Determination of contents was achieved by chromatographic techniques. Extracts were evaluated for antinociceptive activities using hot-plate test; acetic acid-induced writhing test and formalin test. All three extracts of Evodia rutaecarpa showed antinociceptive activities but the ethanol extract exhibited better effect.
CONCLUSIONS:
The better antinociceptive activity appeared to be related to higher contents of evodiamine, rutaecarpine and Evodine in ethanol extract of Evodia rutaecarpa.

Evodine Dilution Calculator

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Evodine Molarity Calculator

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Preparing Stock Solutions of Evodine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0363 mL 15.1814 mL 30.3628 mL 60.7257 mL 75.9071 mL
5 mM 0.6073 mL 3.0363 mL 6.0726 mL 12.1451 mL 15.1814 mL
10 mM 0.3036 mL 1.5181 mL 3.0363 mL 6.0726 mL 7.5907 mL
50 mM 0.0607 mL 0.3036 mL 0.6073 mL 1.2145 mL 1.5181 mL
100 mM 0.0304 mL 0.1518 mL 0.3036 mL 0.6073 mL 0.7591 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Evodine

Antinociceptive activity of aqueous and alcohol extract of evodia rutaecarpa.[Pubmed:25035536]

Indian J Pharm Sci. 2014 May;76(3):235-9.

Water, methanol and ethanol extracts of Evodia rutaecarpa were tested for antinociceptive activity, which were correlated with the contents of evodiamine, rutaecarpine and Evodine. Determination of contents was achieved by chromatographic techniques. Extracts were evaluated for antinociceptive activities using hot-plate test; acetic acid-induced writhing test and formalin test. All three extracts of Evodia rutaecarpa showed antinociceptive activities but the ethanol extract exhibited better effect. The better antinociceptive activity appeared to be related to higher contents of evodiamine, rutaecarpine and Evodine in ethanol extract of Evodia rutaecarpa.

Description

Evodine, the major limonoid of Evodiae Fuctus, is a potent P-gp inhibitor. Evodine has protection against glutamateinduced toxicity by preserving the antioxidant defense system.

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