Guanethidine SulfateCAS# 60-02-6 |
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| Cas No. | 60-02-6 | SDF | Download SDF |
| PubChem ID | 65328 | Appearance | Powder |
| Formula | C20H46N8O4S | M.Wt | 494.7 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO | ||
| Chemical Name | 2-[2-(azocan-1-yl)ethyl]guanidine;sulfuric acid | ||
| SMILES | C1CCCN(CCC1)CCN=C(N)N.C1CCCN(CCC1)CCN=C(N)N.OS(=O)(=O)O | ||
| Standard InChIKey | NBJGGHFXCGHTNJ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/2C10H22N4.H2O4S/c2*11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h2*1-9H2,(H4,11,12,13);(H2,1,2,3,4) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Guanethidine Sulfate Dilution Calculator
Guanethidine Sulfate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0214 mL | 10.1071 mL | 20.2143 mL | 40.4285 mL | 50.5357 mL |
| 5 mM | 0.4043 mL | 2.0214 mL | 4.0429 mL | 8.0857 mL | 10.1071 mL |
| 10 mM | 0.2021 mL | 1.0107 mL | 2.0214 mL | 4.0429 mL | 5.0536 mL |
| 50 mM | 0.0404 mL | 0.2021 mL | 0.4043 mL | 0.8086 mL | 1.0107 mL |
| 100 mM | 0.0202 mL | 0.1011 mL | 0.2021 mL | 0.4043 mL | 0.5054 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antihypertensive; antiglaucoma
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Guanethidine sulfate in the prevention of autonomic hyperreflexia.[Pubmed:458989]
J Urol. 1979 Jul;122(1):55-7.
Autonomic hyperreflexia constitutes the only medical emergency seen in spinal cord injury patients. Uncontrolled hypertension and bradycardia can result in seizures and death. The acute treatment of the syndrome has ranged from medical ganglionic blockers to topical anesthetic agents to surgical procedures. The oral use of 10 mg. Guanethidine Sulfate 3 times daily successfully prevented the major symptoms of the syndrome in 200 spinal cord injury patients with lesions above T5. Toxicity has been mild and the drug is recommended until the patients are voiding and are capable of self-care.
Histologic evaluation of the sympathectomy induced by guanethidine sulfate in neonatal rats.[Pubmed:7130940]
J Exp Zool. 1982 Sep 20;223(1):97-101.
Guanethidine Sulfate was administered to rats from birth to 14 days of age. Cell counts were carried out in the superior cervical sympathetic ganglion at 30, 45, and 90 days of age. Massive permanent destruction of sympathetic ganglionic cells was demonstrated during the experimental period. Evidence for a natural loss of neurons during the morphogenesis of the superior cervical sympathetic ganglion is presented.
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