Tagitinin FCAS# 59979-57-6 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 59979-57-6 | SDF | Download SDF |
| PubChem ID | 5281501 | Appearance | Powder |
| Formula | C19H24O6 | M.Wt | 348.4 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1=CC2C(C(CC3(C=CC1(O3)O)C)OC(=O)C(C)C)C(=C)C(=O)O2 | ||
| Standard InChIKey | XJUPOHKZSDZNBE-QDHYIOMWSA-N | ||
| Standard InChI | InChI=1S/C19H24O6/c1-10(2)16(20)24-14-9-18(5)6-7-19(22,25-18)11(3)8-13-15(14)12(4)17(21)23-13/h6-8,10,13-15,22H,4,9H2,1-3,5H3/b11-8-/t13-,14-,15+,18+,19-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Tagitinin F shows in vitro leishmanicidal activities against Leishmania braziliensis promastigotes and amastigotes. 2. Tagitinin F possesses antileukemic activity. |
| Targets | Antifection |
Tagitinin F Dilution Calculator
Tagitinin F Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8703 mL | 14.3513 mL | 28.7026 mL | 57.4053 mL | 71.7566 mL |
| 5 mM | 0.5741 mL | 2.8703 mL | 5.7405 mL | 11.4811 mL | 14.3513 mL |
| 10 mM | 0.287 mL | 1.4351 mL | 2.8703 mL | 5.7405 mL | 7.1757 mL |
| 50 mM | 0.0574 mL | 0.287 mL | 0.5741 mL | 1.1481 mL | 1.4351 mL |
| 100 mM | 0.0287 mL | 0.1435 mL | 0.287 mL | 0.5741 mL | 0.7176 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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In vitro leishmanicidal activities of sesquiterpene lactones from Tithonia diversifolia against Leishmania braziliensis promastigotes and amastigotes.[Pubmed:24830711]
Molecules. 2014 May 14;19(5):6070-9.
Natural compounds represent a rich and promising source of novel, biologically active chemical entities for treating leishmaniasis. Sesquiterpene lactones are a recognized class of terpenoids with a wide spectrum of biological activities, including activity against Leishmania spp. In this work, a sesquiterpene lactone-rich preparation-a leaf rinse extract (LRE) from Tithonia diversifolia-was tested against promastigote forms of L. braziliensis. The results revealed that the LRE is a rich source of potent leishmanicidal compounds, with an LD50 value 1.5 +/- 0.50 microg.mL-1. Therefore, eight sesquiterpene lactones from the LRE were initially investigated against promastigote forms of L. braziliensis. One of them did not present any significant leishmanicidal effect (LD50 > 50 microg.mL-1). Another had a cytotoxic effect against macrophages (4.5 microg.mL-1). The five leishmanicidal compounds with the highest level of selectivity were further evaluated against intracellular parasites (amastigotes) using peritoneal macrophages. Tirotundin 3-O-methyl ether, Tagitinin F, and a guaianolide reduced the internalization of parasites after 48 h, in comparison with the negative control. This is the first report on sesquiterpene lactones that have potent leishmanicidal effects on both developmental stages of L. braziliensis.
Three new sesquiterpenes from Tithonia diversifolia and their anti-hyperglycemic activity.[Pubmed:22986291]
Fitoterapia. 2012 Dec;83(8):1590-7.
Three new germacrane sesquiterpenes (1), (2), (3), along with eleven known sesquiterpenes, namely, tirotundin-3-O-methyl ether (4), deacetylvguiestin (5), 1beta-hydroxydiversifolin-3-O-methyl ether (6), tagitinin C (7), 1beta-hydroxytirotundin-3-O-methyl ether (8), 1beta-hydroxytirotundin-1,3-O-dimethyl ether (9), Tagitinin F-3-O-methyl ether (10), Tagitinin F (11), tagitinin A (12), 3beta-acetoxy-4alpha-hydroxyeduesm-11(13)-en-12-oic acid (13) and ilicic acid (14) were isolated from the aerial parts of Tithonia diversifolia. Their structures were established by spectroscopic analysis, while the relative configuration of compound 1 was confirmed by X-ray diffraction analysis. In addition, compounds 1-14 were evaluated in vitro for their anti-hyperglycemic activity by glucose uptake in 3T3-L1 adipocytes. It was found that 10mug/mL 1, 3, 6 and 8 could significantly increase glucose uptake without significant toxic effects.
Antileukemic and other constituents of Tithonia tagitiflora Desf.[Pubmed:932981]
J Pharm Sci. 1976 Jun;65(6):918-20.
Phytochemical investigation of Tithonia tagitiflora has led to isolation of six new germacranolides, tagitinins A, B, C, D, E, AND F, beta-sitosterol, and its beta-D-glucoside. Among these, Tagitinin F possesses antileukemic activity.
