Hydrastine

CAS# 118-08-1

Hydrastine

Catalog No. BCC8187----Order now to get a substantial discount!

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Quality Control of Hydrastine

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Chemical structure

Hydrastine

3D structure

Chemical Properties of Hydrastine

Cas No. 118-08-1 SDF Download SDF
PubChem ID 197835 Appearance Powder
Formula C21H21NO6 M.Wt 383.4
Type of Compound Nitrogen-containing Compounds Storage Desiccate at -20°C
Synonyms (-)-β-Hydrastine; (1R,9S)-β-Hydrastine
Solubility Soluble in chloroform
Chemical Name (3S)-6,7-dimethoxy-3-[(5R)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one
SMILES CN1CCC2=CC3=C(C=C2C1C4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OCO3
Standard InChIKey JZUTXVTYJDCMDU-MOPGFXCFSA-N
Standard InChI InChI=1S/C21H21NO6/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19/h4-5,8-9,18-19H,6-7,10H2,1-3H3/t18-,19+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Hydrastine Dilution Calculator

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Hydrastine Molarity Calculator

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Preparing Stock Solutions of Hydrastine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6082 mL 13.0412 mL 26.0824 mL 52.1648 mL 65.2061 mL
5 mM 0.5216 mL 2.6082 mL 5.2165 mL 10.433 mL 13.0412 mL
10 mM 0.2608 mL 1.3041 mL 2.6082 mL 5.2165 mL 6.5206 mL
50 mM 0.0522 mL 0.2608 mL 0.5216 mL 1.0433 mL 1.3041 mL
100 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.5216 mL 0.6521 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Hydrastine

Hydrastine is a natural alkaloid which is present in Hydrastis canadensis and other plants of the ranunculaceae family.

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References on Hydrastine

Hydrastine pharmacokinetics and metabolism after a single oral dose of goldenseal (Hydrastis canadensis) to humans.[Pubmed:25609220]

Drug Metab Dispos. 2015 Apr;43(4):534-52.

The disposition and metabolism of Hydrastine was investigated in 11 healthy subjects following an oral dose of 2.7 g of goldenseal supplement containing 78 mg of Hydrastine. Serial blood samples were collected for 48 hours, and urine was collected for 24 hours. Hydrastine serum and urine concentrations were determined by Liquid Chromatography-tandem mass spectrometry (LC-MS/MS). Pharmacokinetic parameters for Hydrastine were calculated using noncompartmental methods. The maximal serum concentration (Cmax) was 225 +/- 100 ng/ml, Tmax was 1.5 +/- 0.3 hours, and area under the curve was 6.4 +/- 4.1 ng h/ml kg. The elimination half-life was 4.8 +/- 1.4 hours. Metabolites of Hydrastine were identified in serum and urine by using liquid chromatography coupled to high-resolution mass spectrometry. Hydrastine metabolites were identified by various mass spectrometric techniques, such as accurate mass measurement, neutral loss scanning, and product ion scanning using Quadrupole-Time of Flight (Q-ToF) and triple quadrupole instruments. The identity of phase II metabolites was further confirmed by hydrolysis of glucuronide and sulfate conjugates using bovine beta-glucuronidase and a Helix pomatia sulfatase/glucuronidase enzyme preparation. Hydrastine was found to undergo rapid and extensive phase I and phase II metabolism. Reduction, O-demethylation, N-demethylation, hydroxylation, aromatization, lactone hydrolysis, and dehydrogenation of the alcohol group formed by lactone hydrolysis to the ketone group were observed during phase I biotransformation of Hydrastine. Phase II metabolites were primarily glucuronide and sulfate conjugates. Hydrastine undergoes extensive biotransformation, and some metabolites may have pharmacological activity. Further study is needed in this area.

Description

Hydrastine is a natural alkaloid which is present in Hydrastis canadensis and other plants of the ranunculaceae family.

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