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Lasiocarpine N-oxide

CAS# 127-30-0

Lasiocarpine N-oxide

Catalog No. BCN2002----Order now to get a substantial discount!

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Lasiocarpine N-oxide: 5mg Please Inquire In Stock
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Lasiocarpine N-oxide: 1000mg Please Inquire Please Inquire

Quality Control of Lasiocarpine N-oxide

Number of papers citing our products

Chemical structure

Lasiocarpine N-oxide

3D structure

Chemical Properties of Lasiocarpine N-oxide

Cas No. 127-30-0 SDF Download SDF
PubChem ID 5458800 Appearance White powder
Formula C21H33NO8 M.Wt 427.49
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in methanol and water; sparingly soluble in ethyl acetate
Chemical Name [(7S,8R)-7-[(Z)-2-methylbut-2-enoyl]oxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl]methyl (2R)-2,3-dihydroxy-2-[(1S)-1-methoxyethyl]-3-methylbutanoate
SMILES CC=C(C)C(=O)OC1CC[N+]2(C1C(=CC2)COC(=O)C(C(C)OC)(C(C)(C)O)O)[O-]
Standard InChIKey AABILZKQMVKFHP-LRBDFNDQSA-N
Standard InChI InChI=1S/C21H33NO8/c1-7-13(2)18(23)30-16-9-11-22(27)10-8-15(17(16)22)12-29-19(24)21(26,14(3)28-6)20(4,5)25/h7-8,14,16-17,25-26H,9-12H2,1-6H3/b13-7-/t14-,16-,17+,21-,22?/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lasiocarpine N-oxide

1 Symphytum sp.

Biological Activity of Lasiocarpine N-oxide

Description1. Lasiocarpine-N-oxide shows antimicrobial activity against selected pathogenic bacteria and fungi.
TargetsAntifection

Lasiocarpine N-oxide Dilution Calculator

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Lasiocarpine N-oxide Molarity Calculator

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Preparing Stock Solutions of Lasiocarpine N-oxide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3392 mL 11.6962 mL 23.3924 mL 46.7847 mL 58.4809 mL
5 mM 0.4678 mL 2.3392 mL 4.6785 mL 9.3569 mL 11.6962 mL
10 mM 0.2339 mL 1.1696 mL 2.3392 mL 4.6785 mL 5.8481 mL
50 mM 0.0468 mL 0.2339 mL 0.4678 mL 0.9357 mL 1.1696 mL
100 mM 0.0234 mL 0.117 mL 0.2339 mL 0.4678 mL 0.5848 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Lasiocarpine N-oxide

Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides.[Pubmed:28987376]

J Food Drug Anal. 2017 Oct;25(4):984-991.

There are 660 pyrrolizidine alkaloids (PAs) and PA N-oxides present in the plants, with approximately half being possible carcinogens. We previously reported that a set of four PA-derived DNA adducts is formed in the liver of rats administered a series of hepatocarcinogenic PAs and a PA N-oxide. Based on our findings, we hypothesized that this set of DNA adducts is a common biological biomarker of PA-induced liver tumor formation. In this study, we determined that rat liver microsomal metabolism of five hepatocarcinogenic PAs (lasiocarpine, retrorsine, riddelliine, monocrotaline, and heliotrine) and their corresponding PA N-oxides produced the same set of DNA adducts. Among these compounds, Lasiocarpine N-oxide, retrorsine N-oxide, monocrotaline N-oxide, and heliotrine N-oxide are for first time shown to be able to produce these DNA adducts. These results further support the role of these DNA adducts as potential common biomarkers of PA-induced liver tumor initiation.

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