Meptazinol HCl

CAS# 59263-76-2

Meptazinol HCl

Catalog No. BCC4920----Order now to get a substantial discount!

Product Name & Size Price Stock
Meptazinol HCl: 5mg $23 In Stock
Meptazinol HCl: 10mg Please Inquire In Stock
Meptazinol HCl: 20mg Please Inquire Please Inquire
Meptazinol HCl: 50mg Please Inquire Please Inquire
Meptazinol HCl: 100mg Please Inquire Please Inquire
Meptazinol HCl: 200mg Please Inquire Please Inquire
Meptazinol HCl: 500mg Please Inquire Please Inquire
Meptazinol HCl: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Meptazinol HCl

Number of papers citing our products

Chemical structure

Meptazinol HCl

3D structure

Chemical Properties of Meptazinol HCl

Cas No. 59263-76-2 SDF Download SDF
PubChem ID 65483 Appearance Powder
Formula C15H24ClNO M.Wt 269.81
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in water and to 75 mM in DMSO
Chemical Name 3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenol hydrochloride
SMILES [H+].[Cl-].CCC1(CCCCN(C)C1)c2cccc(O)c2
Standard InChIKey MPJUSISYVXABBH-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H23NO.ClH/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13;/h6-8,11,17H,3-5,9-10,12H2,1-2H3;1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Meptazinol HCl

DescriptionCentrally active opioid analgesic. Partial agonist at the μ1 opioid receptor. Also shown to inhibit acetylcholinesterase.

Meptazinol HCl Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Meptazinol HCl Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Meptazinol HCl

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7063 mL 18.5316 mL 37.0631 mL 74.1262 mL 92.6578 mL
5 mM 0.7413 mL 3.7063 mL 7.4126 mL 14.8252 mL 18.5316 mL
10 mM 0.3706 mL 1.8532 mL 3.7063 mL 7.4126 mL 9.2658 mL
50 mM 0.0741 mL 0.3706 mL 0.7413 mL 1.4825 mL 1.8532 mL
100 mM 0.0371 mL 0.1853 mL 0.3706 mL 0.7413 mL 0.9266 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Meptazinol HCl

Meptazinol Hcl(WY-22811 Hcl) is a unique centrally active opioid analgesic.

Featured Products
New Products
 

References on Meptazinol HCl

Meptazinol: a novel Mu-1 selective opioid analgesic.[Pubmed:6141283]

J Pharmacol Exp Ther. 1984 Feb;228(2):414-9.

Meptazinol is a unique centrally active opioid analgesic, differing in many respects from the classical opiates or mixed antagonists. Although the overall binding of a series of 3H-labeled opioids is displaced poorly (IC50 values greater than 55 nM), detailed competition studies show that meptazinol inhibits a portion of 3H-labeled opiate and opioid peptide binding quite potently, with IC50 value under 1 nM. Both additional competition studies and saturation studies indicate that the meptazinol-sensitive binding of the 3H-ligands corresponds to the high affinity, or mu-1, binding site. In other binding studies meptazinol has a sodium shift of 8.7, midway between that of morphine (22.5) and naloxone (1.6), suggesting that it is a partial agonist. Naloxonazine treatment 24 hr earlier attenuates meptazinol analgesia in both the mouse writhing and rat tail-flick assays. Spinal transection in the mouse completely eliminates the analgesic activity of high doses of meptazinol in the tail-flick assay, implying a supraspinal mechanism of action in that species. Given at equianalgesic doses, morphine (3.5 mg/kg i.v.) significantly lowers the pO2 over 20 mm Hg and raises the pCO2 over 10 mm Hg as measured in arterial blood samples, whereas meptazinol (10 mg/kg i.v.) has no significant effects on either. Equally important, meptazinol administered with morphine does not reverse the respiratory depressant actions seen with morphine alone, distinguishing meptazinol from other mixed agonist/antagonists. Thus, both the binding and in vivo pharmacological studies are consistent with a mu-1 selective mechanism for the opioid actions of meptazinol.

Description

Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM.

Keywords:

Meptazinol HCl,59263-76-2,Natural Products,Opioid Receptor, buy Meptazinol HCl , Meptazinol HCl supplier , purchase Meptazinol HCl , Meptazinol HCl cost , Meptazinol HCl manufacturer , order Meptazinol HCl , high purity Meptazinol HCl

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: