Meptazinol HClCAS# 59263-76-2 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 59263-76-2 | SDF | Download SDF |
PubChem ID | 65483 | Appearance | Powder |
Formula | C15H24ClNO | M.Wt | 269.81 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble to 100 mM in water and to 75 mM in DMSO | ||
Chemical Name | 3-(3-Ethylhexahydro-1-methyl-1H-aze | ||
SMILES | [H+].[Cl-].CCC1(CCCCN(C)C1)c2cccc(O)c2 | ||
Standard InChIKey | MPJUSISYVXABBH-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C15H23NO.ClH/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13;/h6-8,11,17H,3-5,9-10,12H2,1-2H3;1H | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Centrally active opioid analgesic. Partial agonist at the μ1 opioid receptor. Also shown to inhibit acetylcholinesterase. |
Meptazinol HCl Dilution Calculator
Meptazinol HCl Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.7063 mL | 18.5316 mL | 37.0631 mL | 74.1262 mL | 92.6578 mL |
5 mM | 0.7413 mL | 3.7063 mL | 7.4126 mL | 14.8252 mL | 18.5316 mL |
10 mM | 0.3706 mL | 1.8532 mL | 3.7063 mL | 7.4126 mL | 9.2658 mL |
50 mM | 0.0741 mL | 0.3706 mL | 0.7413 mL | 1.4825 mL | 1.8532 mL |
100 mM | 0.0371 mL | 0.1853 mL | 0.3706 mL | 0.7413 mL | 0.9266 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Meptazinol Hcl(WY-22811 Hcl) is a unique centrally active opioid analgesic.
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Meptazinol: a novel Mu-1 selective opioid analgesic.[Pubmed:6141283]
J Pharmacol Exp Ther. 1984 Feb;228(2):414-9.
Meptazinol is a unique centrally active opioid analgesic, differing in many respects from the classical opiates or mixed antagonists. Although the overall binding of a series of 3H-labeled opioids is displaced poorly (IC50 values greater than 55 nM), detailed competition studies show that meptazinol inhibits a portion of 3H-labeled opiate and opioid peptide binding quite potently, with IC50 value under 1 nM. Both additional competition studies and saturation studies indicate that the meptazinol-sensitive binding of the 3H-ligands corresponds to the high affinity, or mu-1, binding site. In other binding studies meptazinol has a sodium shift of 8.7, midway between that of morphine (22.5) and naloxone (1.6), suggesting that it is a partial agonist. Naloxonazine treatment 24 hr earlier attenuates meptazinol analgesia in both the mouse writhing and rat tail-flick assays. Spinal transection in the mouse completely eliminates the analgesic activity of high doses of meptazinol in the tail-flick assay, implying a supraspinal mechanism of action in that species. Given at equianalgesic doses, morphine (3.5 mg/kg i.v.) significantly lowers the pO2 over 20 mm Hg and raises the pCO2 over 10 mm Hg as measured in arterial blood samples, whereas meptazinol (10 mg/kg i.v.) has no significant effects on either. Equally important, meptazinol administered with morphine does not reverse the respiratory depressant actions seen with morphine alone, distinguishing meptazinol from other mixed agonist/antagonists. Thus, both the binding and in vivo pharmacological studies are consistent with a mu-1 selective mechanism for the opioid actions of meptazinol.