Moracenin DCAS# 78277-79-9 |
| Cas No. | 78277-79-9 | SDF | File under preparation. |
| PubChem ID | 162856216.0 | Appearance | Powder |
| Formula | C40H38O12 | M.Wt | 710.7 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 8-[(1S,5R,6S)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-hydroxy-3-methylbutyl)chromen-4-one | ||
| SMILES | CC1=CC(C(C(C1)C2=C(C=C(C=C2)O)O)C(=O)C3=C(C=C(C=C3)O)O)C4=C(C=C(C5=C4OC(=C(C5=O)CCC(C)(C)O)C6=C(C=C(C=C6)O)O)O)O | ||
| Standard InChIKey | PYXAHGLTSLDDJH-SECNDIFOSA-N | ||
| Standard InChI | InChI=1S/C40H38O12/c1-18-12-26(22-7-4-19(41)14-28(22)44)33(36(49)23-8-5-20(42)15-29(23)45)27(13-18)34-31(47)17-32(48)35-37(50)25(10-11-40(2,3)51)38(52-39(34)35)24-9-6-21(43)16-30(24)46/h4-9,13-17,26-27,33,41-48,51H,10-12H2,1-3H3/t26-,27-,33-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Quality Control & MSDS
3D structure
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Moracenin D Dilution Calculator
Moracenin D Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.4071 mL | 7.0353 mL | 14.0706 mL | 28.1413 mL | 35.1766 mL |
| 5 mM | 0.2814 mL | 1.4071 mL | 2.8141 mL | 5.6283 mL | 7.0353 mL |
| 10 mM | 0.1407 mL | 0.7035 mL | 1.4071 mL | 2.8141 mL | 3.5177 mL |
| 50 mM | 0.0281 mL | 0.1407 mL | 0.2814 mL | 0.5628 mL | 0.7035 mL |
| 100 mM | 0.0141 mL | 0.0704 mL | 0.1407 mL | 0.2814 mL | 0.3518 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Tyrosinase inhibition constituents from the roots of Morus australis.[Pubmed:22698714]
Fitoterapia. 2012 Sep;83(6):1008-13.
The phytochemical profiles of Morus australis roots, stems and twigs were firstly compared by HPLC analysis. It was found that Morus australis stem extract mainly contained one known tyrosinase inhibitor, oxyresveratrol, while its root and twig extract might contain some unknown potential tyrosinase inhibitors. The root extract of Morus australis was further investigated in this study. One new compound, austraone A, together with 21 known compounds, was isolated and their structures were identified by interpretation of MS and NMR data. In the tyrosinase inhibitory testing, some of them, such as oxyresveratrol, Moracenin D, sanggenon T, and kuwanon O, exhibited stronger tyrosinase inhibitory activities than that of kojic acid. These results suggested the Morus australis root extract as a good source of natural tyrosinase inhibitors with a great potential to be used in foods as anti-browning agents and in cosmetics as skin-whitening agents.
Moracenin D from Mori Cortex radicis protects SH-SY5Y cells against dopamine-induced cell death by regulating nurr1 and alpha-synuclein expression.[Pubmed:21936000]
Phytother Res. 2012 Apr;26(4):620-4.
In our efforts to find neuroprotective materials of plant origin, several compounds were isolated from Mori Cortex Radicis. The protective effect against dopamine-induced cell death was examined, and the subsequent effects on the levels of expression of Parkinson's disease-associated nurr1 and alpha-synuclein were evaluated in a dopamine-induced system. Five compounds were isolated and Moracenin D protected cell death against dopamine-induction in human neuroblastoma SH-SY5Y cells. The effects of Moracenin D on the levels of mRNA and protein expression of nurr1 and alpha-synuclein were subsequently examined using reverse transcription-polymerase chain reaction (RT-PCR) and western blot analysis. Treatment with Moracenin D resulted in an up-regulation of nurr1 mRNA levels and a down-regulation of alpha-synuclein mRNA levels. Additionally, the alpha-synuclein protein expression was decreased in accordance with an increase in nurr1 protein expression. These results demonstrate that the protective effects of Moracenin D were presumably due to the correlative effects on the up-regulation of nurr1 and down-regulation of alpha-synuclein expressions against dopamine induction. Therefore, Moracenin D can be considered as a candidate for therapy for Parkinson's disease.
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