PilloinCAS# 32174-62-2 |
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3D structure
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Number of papers citing our products
| Cas No. | 32174-62-2 | SDF | Download SDF |
| PubChem ID | 5320496 | Appearance | Powder |
| Formula | C17H14O6 | M.Wt | 314.29 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxychromen-4-one | ||
| SMILES | COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC)O)O | ||
| Standard InChIKey | UDBHJDTXPDRDNS-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H14O6/c1-21-10-6-12(19)17-13(20)8-15(23-16(17)7-10)9-3-4-14(22-2)11(18)5-9/h3-8,18-19H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Pilloin exerts a cytotoxic action targeted at the transformed lymphoblasts. |
| In vitro | Effects of the Flavonoid Pilloin Isolated from Marrubium cylleneum on Mitogen-Induced Lymphocyte Transformation[Reference: WebLink]Pharmaceutical Biology, 2008, 40(4):245-248.Flavonoids are known to exhibit a wide range of biological functions. |
Pilloin Dilution Calculator
Pilloin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1818 mL | 15.9089 mL | 31.8177 mL | 63.6355 mL | 79.5444 mL |
| 5 mM | 0.6364 mL | 3.1818 mL | 6.3635 mL | 12.7271 mL | 15.9089 mL |
| 10 mM | 0.3182 mL | 1.5909 mL | 3.1818 mL | 6.3635 mL | 7.9544 mL |
| 50 mM | 0.0636 mL | 0.3182 mL | 0.6364 mL | 1.2727 mL | 1.5909 mL |
| 100 mM | 0.0318 mL | 0.1591 mL | 0.3182 mL | 0.6364 mL | 0.7954 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Pilloin, A Flavonoid Isolated from Aquilaria sinensis, Exhibits Anti-Inflammatory Activity In Vitro and In Vivo.[Pubmed:30513815]
Molecules. 2018 Dec 2;23(12). pii: molecules23123177.
Flavonoids, widely present in medicinal plants and fruits, are known to exhibit multiple pharmacological activities. In this study, we isolated a flavonoid compound, Pilloin, from Aquilaria sinensis and investigated its anti-inflammatory activity in bacterial lipopolysaccharide-induced RAW 264.7 macrophages and septic mice. Pilloin inhibited NF-kappaB activation and reduced the phosphorylation of IkappaB in LPS-stimulated macrophages. Moreover, Pilloin significantly suppressed the production of pro-inflammatory molecules, such as TNF-alpha, IL-6, COX-2 and iNOS, in LPS-treated RAW 264.7 macrophages. Additionally, Pilloin suppressed LPS-induced morphological alterations, phagocytic activity and ROS elevation in RAW 264.7 macrophages. The mitogen-activated protein kinase-mediated signalling pathways (including JNK, ERK, p38) were also inhibited by Pilloin. Furthermore, Pilloin reduced serum levels of TNF-alpha (from 123.3 +/- 7 to 46.6 +/- 5.4 ng/mL) and IL-6 levels (from 1.4 +/- 0.1 to 0.7 +/- 0.1 ng/mL) in multiple organs of LPS-induced septic mice (liver: from 71.8 +/- 3.2 to 36.7 +/- 4.3; lung: from 118.6 +/- 10.6 to 75.8 +/- 11.9; spleen: from 185.9 +/- 23.4 to 109.6 +/- 18.4; kidney: from 160.3 +/- 11.8 to 75 +/- 10.8 pg/mL). In summary, our results demonstrate the anti-inflammatory potential of Pilloin and reveal its underlying molecular mechanism of action.
Pilloin 5-O-beta-D-glucopyranoside from the stems of Diplomorpha ganpi.[Pubmed:22878190]
Biosci Biotechnol Biochem. 2012;76(8):1555-7.
The new flavonoid, Pilloin 5-O-beta-D-glucopyranoside (1), was isolated from the stems of Diplomorpha ganpi (Family: Thymelaeaceae) together with 19 known compounds. The structures of these compounds were determined on the basis of spectroscopic data.
