Pilloin

CAS# 32174-62-2

Pilloin

Catalog No. BCN6817----Order now to get a substantial discount!

Product Name & Size Price Stock
Pilloin: 5mg $690 In Stock
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Quality Control of Pilloin

Number of papers citing our products

Chemical structure

Pilloin

3D structure

Chemical Properties of Pilloin

Cas No. 32174-62-2 SDF Download SDF
PubChem ID 5320496 Appearance Powder
Formula C17H14O6 M.Wt 314.29
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxychromen-4-one
SMILES COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC)O)O
Standard InChIKey UDBHJDTXPDRDNS-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H14O6/c1-21-10-6-12(19)17-13(20)8-15(23-16(17)7-10)9-3-4-14(22-2)11(18)5-9/h3-8,18-19H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Pilloin

The herbs of Marrubium cylleneum

Biological Activity of Pilloin

DescriptionPilloin exerts a cytotoxic action targeted at the transformed lymphoblasts.
In vitro

Effects of the Flavonoid Pilloin Isolated from Marrubium cylleneum on Mitogen-Induced Lymphocyte Transformation[Reference: WebLink]

Pharmaceutical Biology, 2008, 40(4):245-248.

Flavonoids are known to exhibit a wide range of biological functions.
METHODS AND RESULTS:
In the present study, the possible immunomodulatory and cytotoxic effects of Pilloin, a flavone extracted from the Greek endemic herb Marrubium cylleneum were investigated by using the in vitro lymphocyte transformation and the cytotoxicity assays, respectively. Apigenin was used as the control flavonoid.
CONCLUSIONS:
Pilloin exerted a cytotoxic action targeted at the transformed lymphoblasts. On the other hand, the glycosylated flavonoid chrysoeriol-7- O -ß-D-(3β- E-p -coumaroyl)-glucopyranoside was inactive, providing further evidence that glycosylation may eliminate the effects of aglycones.

Pilloin Dilution Calculator

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Pilloin Molarity Calculator

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Preparing Stock Solutions of Pilloin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1818 mL 15.9089 mL 31.8177 mL 63.6355 mL 79.5444 mL
5 mM 0.6364 mL 3.1818 mL 6.3635 mL 12.7271 mL 15.9089 mL
10 mM 0.3182 mL 1.5909 mL 3.1818 mL 6.3635 mL 7.9544 mL
50 mM 0.0636 mL 0.3182 mL 0.6364 mL 1.2727 mL 1.5909 mL
100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.6364 mL 0.7954 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Pilloin

Pilloin, A Flavonoid Isolated from Aquilaria sinensis, Exhibits Anti-Inflammatory Activity In Vitro and In Vivo.[Pubmed:30513815]

Molecules. 2018 Dec 2;23(12). pii: molecules23123177.

Flavonoids, widely present in medicinal plants and fruits, are known to exhibit multiple pharmacological activities. In this study, we isolated a flavonoid compound, Pilloin, from Aquilaria sinensis and investigated its anti-inflammatory activity in bacterial lipopolysaccharide-induced RAW 264.7 macrophages and septic mice. Pilloin inhibited NF-kappaB activation and reduced the phosphorylation of IkappaB in LPS-stimulated macrophages. Moreover, Pilloin significantly suppressed the production of pro-inflammatory molecules, such as TNF-alpha, IL-6, COX-2 and iNOS, in LPS-treated RAW 264.7 macrophages. Additionally, Pilloin suppressed LPS-induced morphological alterations, phagocytic activity and ROS elevation in RAW 264.7 macrophages. The mitogen-activated protein kinase-mediated signalling pathways (including JNK, ERK, p38) were also inhibited by Pilloin. Furthermore, Pilloin reduced serum levels of TNF-alpha (from 123.3 +/- 7 to 46.6 +/- 5.4 ng/mL) and IL-6 levels (from 1.4 +/- 0.1 to 0.7 +/- 0.1 ng/mL) in multiple organs of LPS-induced septic mice (liver: from 71.8 +/- 3.2 to 36.7 +/- 4.3; lung: from 118.6 +/- 10.6 to 75.8 +/- 11.9; spleen: from 185.9 +/- 23.4 to 109.6 +/- 18.4; kidney: from 160.3 +/- 11.8 to 75 +/- 10.8 pg/mL). In summary, our results demonstrate the anti-inflammatory potential of Pilloin and reveal its underlying molecular mechanism of action.

Pilloin 5-O-beta-D-glucopyranoside from the stems of Diplomorpha ganpi.[Pubmed:22878190]

Biosci Biotechnol Biochem. 2012;76(8):1555-7.

The new flavonoid, Pilloin 5-O-beta-D-glucopyranoside (1), was isolated from the stems of Diplomorpha ganpi (Family: Thymelaeaceae) together with 19 known compounds. The structures of these compounds were determined on the basis of spectroscopic data.

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