Podoverine A

Name: Podoverine A
Brand: BioCrick
SKU: BCX2908

CAS# 107882-43-9

Podoverine A 2D chemical structure

2D Structure

Catalog No. BCX2908----Order now to get a substantial discount!

Product Name & Size	Price	Stock
Podoverine A: 5mg	Please Inquire	In Stock
Podoverine A: 10mg	Please Inquire	In Stock
Podoverine A: 20mg	Please Inquire	Please Inquire
Podoverine A: 50mg	Please Inquire	Please Inquire
Podoverine A: 100mg	Please Inquire	Please Inquire
Podoverine A: 200mg	Please Inquire	Please Inquire
Podoverine A: 500mg	Please Inquire	Please Inquire
Podoverine A: 1000mg	Please Inquire	Please Inquire

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Chemical Properties of Podoverine A

Cas No.	107882-43-9	SDF	File under preparation.
PubChem ID	13911680.0	Appearance	Powder
Formula	C21H20O7	M.Wt	384.4
Type of Compound	N/A	Storage	Desiccate at -20°C
Solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name	2-[3,4-dihydroxy-2-(3-methylbut-2-enyl)phenyl]-5,7-dihydroxy-3-methoxychromen-4-one
SMILES	CC(=CCC1=C(C=CC(=C1O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC)C
Standard InChIKey	MGFXFQXRHGAKQN-UHFFFAOYSA-N
Standard InChI	InChI=1S/C21H20O7/c1-10(2)4-5-12-13(6-7-14(23)18(12)25)20-21(27-3)19(26)17-15(24)8-11(22)9-16(17)28-20/h4,6-9,22-25H,5H2,1-3H3
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Quality Control of Podoverine A

Quality Control & MSDS

Purity: >98%

3D structure

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Number of papers citing our products

Podoverine A Dilution Calculator

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Similar Structures

Preparing Stock Solutions of Podoverine A

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6015 mL	13.0073 mL	26.0146 mL	52.0291 mL	65.0364 mL
5 mM	0.5203 mL	2.6015 mL	5.2029 mL	10.4058 mL	13.0073 mL
10 mM	0.2601 mL	1.3007 mL	2.6015 mL	5.2029 mL	6.5036 mL
50 mM	0.052 mL	0.2601 mL	0.5203 mL	1.0406 mL	1.3007 mL
100 mM	0.026 mL	0.1301 mL	0.2601 mL	0.5203 mL	0.6504 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on Podoverine A

[A new biflavone from Dysosma versipellis].[Pubmed:29905994]

Yao Xue Xue Bao. 2016 Aug;51(8):1281-4.

This study was conducted to investigate the chemical constituents in the root of Dysosma versipellis(Hance) M. Cheng. The constituents were isolated by silica gel, lichroprep RP-C(18) and pharmadex LH-20 column chromatography and the IR, MS, NMR, 2D-NMR spectroscopic analysis were employed for the structural elucidation. Ten compounds were isolated from the 95% ethanol extract of Dysosma versipellis, their structures were elucidated as dysoverine D (1), dysoverine F (2), dysoverine A (3), Podoverine A (4), alpha-peltatin (5), rutin (6), kaempferol-3-O-beta-D-glucopyranoside (7), quercetin-3-O-beta-D-glucopyranoside (8), kaempferol (9) and quercetin (10). Compound 2 is a new compound, and compounds 1 and 3-6 were isolated from this plant for the first time.

Podoverine A--a novel microtubule destabilizing natural product from the Podophyllum species.[Pubmed:24530033]

Bioorg Med Chem. 2014 Sep 15;22(18):5110-6.

Natural products represent compound classes with high chemical and structural diversity and various biological activities. Libraries based on natural products are valuable starting point in the search for novel biologically active substances. Here we report on the identification of the natural product Podoverine A from the plant Podophyllum versipelle Hance as a novel tubulin-acting agent. A natural product compound collection was subjected to a high-content screen that monitors changes in cytoskeleton and DNA and Podoverine A was identified as inhibitor of mitosis. This natural product causes mitotic arrest and inhibits microtubule polymerization in vitro and in cells by targeting the vinca binding site on tubulin.

Product Information

Podoverine A (CAS 107882-43-9) is a natural product offered by BioCrick for research applications. Customers can buy or order Podoverine A from BioCrick, a supplier and manufacturer of research chemicals, with product specifications, purity, packaging, and pricing information available upon request.