PseudojervineCAS# 36069-05-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 36069-05-3 | SDF | Download SDF |
PubChem ID | 16398499.0 | Appearance | Powder |
Formula | C33H49NO8 | M.Wt | 587.75 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyspiro[1,2,3,4,6,6a,6b,7,8,11a-decahydrobenzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-11-one | ||
SMILES | CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5C(=O)C4=C3C)C)OC7C(C(C(C(O7)CO)O)O)O)C)NC1 | ||
Standard InChIKey | HYDDDNUKNMMWBD-VPLHBGEQSA-N | ||
Standard InChI | InChI=1S/C33H49NO8/c1-15-11-22-26(34-13-15)17(3)33(42-22)10-8-20-21-6-5-18-12-19(40-31-30(39)29(38)27(36)23(14-35)41-31)7-9-32(18,4)25(21)28(37)24(20)16(33)2/h5,15,17,19-23,25-27,29-31,34-36,38-39H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,22+,23+,25+,26-,27+,29-,30+,31+,32-,33-/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Pseudojervine Dilution Calculator
Pseudojervine Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.7014 mL | 8.507 mL | 17.014 mL | 34.0281 mL | 42.5351 mL |
5 mM | 0.3403 mL | 1.7014 mL | 3.4028 mL | 6.8056 mL | 8.507 mL |
10 mM | 0.1701 mL | 0.8507 mL | 1.7014 mL | 3.4028 mL | 4.2535 mL |
50 mM | 0.034 mL | 0.1701 mL | 0.3403 mL | 0.6806 mL | 0.8507 mL |
100 mM | 0.017 mL | 0.0851 mL | 0.1701 mL | 0.3403 mL | 0.4254 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- BoeravinoneA
Catalog No.:BCX0923
CAS No.:114567-33-8
- D-Pyroglutamicacid
Catalog No.:BCX0922
CAS No.:4042-36-8
- VanillylButylEther
Catalog No.:BCX0921
CAS No.:82654-98-6
- SalicylaldehydeAzine
Catalog No.:BCX0920
CAS No.:959-36-4
- 4-Dimethylaminobenzaldehyde
Catalog No.:BCX0919
CAS No.:100-10-7
- Cinnamylacetate
Catalog No.:BCX0918
CAS No.:103-54-8
- 8-Methoxyquinoline-2-carbaldehyde
Catalog No.:BCX0917
CAS No.:103854-64-4
- PALATINOSE
Catalog No.:BCX0916
CAS No.:13718-94-0
- Chlorine6
Catalog No.:BCX0915
CAS No.:19660-77-6
- Climbazole
Catalog No.:BCX0914
CAS No.:38083-17-9
- Oxysophoridine
Catalog No.:BCX0913
CAS No.:54809-74-4
- Graniline
Catalog No.:BCX0912
CAS No.:40737-97-1
- MogrosideIIA
Catalog No.:BCX0925
CAS No.:1613527-65-3
- 14-Deoxy-11-oxoandrographolide
Catalog No.:BCX0926
CAS No.:42895-57-8
- Hydroxyisogermafurenolide
Catalog No.:BCX0927
CAS No.:20267-91-8
- (+)-Pinoresinolmonomethylether4-O-β-D-glucoside
Catalog No.:BCX0928
CAS No.:74957-57-6
- 3-(3-hydroxylphenyl)propanol
Catalog No.:BCX0929
CAS No.:621-54-5
- PhysalinF
Catalog No.:BCX0930
CAS No.:57517-46-1
- Cepharanoline
Catalog No.:BCX0931
CAS No.:27686-34-6
- Nicotinamidemononucleotide
Catalog No.:BCX0932
CAS No.:1094-61-7
- 2-Methoxybenzoicacid
Catalog No.:BCX0933
CAS No.:529-75-9
- Hydroxypinacolone Retinoate
Catalog No.:BCX0934
CAS No.:893412-73-2
- Coumarin 343
Catalog No.:BCX0935
CAS No.:55804-65-4
- LINOLELAIDICACIDMETHYLESTER
Catalog No.:BCX0936
CAS No.:2566-97-4
Exploring the hypoglycaemic efficacy of bio-accessed antioxidative polyphenolics in thermally processed Cucumis dipsaceus fruits - An in vitro and in silico study.[Pubmed:37804734]
Food Chem. 2024 Mar 1;435:137577.
Inhibition of breakdown of dietary carbohydrates, by controlling the postprandial activity of diabetic enzymes through fruit polyphenolics can help downregulate the effects of Type 2 Diabetes Mellitus (T2DM). The study focuses on deciphering the induction of hyperglycaemic control by bio-accessed anti-oxidative polyphenols of Cucumic dipsaceus fruits. Chiefly, we examined the antioxidant activity of bio-accessed polyphenols of C. dipsaceus fruits (DPPH: ME (GDE)-66.26 %; ABTS: FE (IDE)-1963.83 microM TEAC/mg extract; Phosphomolybdenum reduction: FE (IDE)- 64.95 mg AAEAC/g extract). To add more significance, the anti-diabetic activity was predetermined by in silico docking analyses (Pseudojervine - -5.43; Squalene- -10.41) and was concurrently confirmed by in vitro studies (alpha amylase inhibition: ME (GDE) - 69.58 %; alpha glucosidase inhibition: FE (UDE)- 88.67 %). A higher bio-accessibility of rutin (37.92 mg/g ODE) and gallic acid (8.36 mg/g ODE) was observed after quantification by HPLC, which confirmed the correlation between anti-diabetic activity and C. dipsaceus fruit phenolic compounds.
Quantitative determination of six steroid alkaloids by sensitive hydrophilic interaction liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic study in rats.[Pubmed:30187929]
Biomed Chromatogr. 2019 Jan;33(1):e4377.
In this study, a sensitive hydrophilic interaction liquid chromatography (HILIC) method was developed to determine Pseudojervine (PJV), veratrosine (VTS), jervine (JV), veratramine (VTM), veramarine (VA) and veratroylzygadenine (VTG) in rat plasma. Separations were carried out using LC-MS/MS with a Chrom Matrix HP amide column (5 m, 10 cm x 3.0 mm i.d.). The mobile phases were (A) 0.01 mm formic acid and (B) acetonitrile. Good linearity was found for all analytes (R(2) > 0.995) in the concentration range from 5 to 1000 mug/L with LLOQ at 5 mug/L for VTM and VTS; and from 1 to 1000 mug/L with LLOQ at 1 mug/L for PJV, JV, VA and VTG. Accuracy of the assay varied from 90.5 to 108.1%. The extraction recovery and matrix effect of six analytes ranged from 72.2 to 95.5% and from 79.2 to 98.4%. According to the stability test, six analytes in rat plasma were stable during the analysis process. On the basis of validation of the assay, the pharmacokinetics of the six steroid alkaloids were investigated after oral administration of Lilu extracts to rats.
Insecticidal metabolites from the rhizomes of Veratrum album against adults of Colorado potato beetle, Leptinotarsa decemlineata.[Pubmed:25146763]
Chem Biodivers. 2014 Aug;11(8):1192-204.
The dried rhizomes of Veratrum album were individually extracted with CHCl3 , acetone, and NH4 OH/benzene to test the toxic effects against the Colorado potato beetle, Leptinotarsa decemlineata, which is an important agricultural pest. Fifteen compounds in various amounts were isolated from the extracts using column and thin-layer chromatography. The chemical structures of 14 compounds were characterized as octacosan-1-ol (1), beta-sitosterol (2), stearic acid (3), diosgenin (4), resveratrol (5), wittifuran X (6), oxyresveratrol (7), beta-sitosterol 3-O-beta-D-glucopyranoside (8), diosgenin 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyronoside (9), oxyresveratrol 3-O-beta-D-glucopyranoside (10), jervine (11), Pseudojervine (13), 5,6-dihydro-1-hydroxyjervine (14), and saccharose (15) using UV, IR, MS, (1) H- and (13)C-NMR, and 2D-NMR spectroscopic methods. However, the chemical structure of 12, an oligosaccharide, has not fully been elucidated. Compounds 4, 6, 9, and 10 were isolated from V. album rhizomes for the first time in the current study. The toxic effects of three extracts (acetone, CHCl3 , and NH4 OH/benzene) and six metabolites, 2, 2+4, 5, 7, 8, and 11, were evaluated against the Colorado potato beetle. The assay revealed that all three extracts, and compounds 7, 8, and 11 exhibited potent toxic effects against this pest. This is the first report on the evaluation of the toxic effects of the extracts and secondary metabolites of V. album rhizomes against L. decemlineata. Based on these results, it can be concluded that the extracts can be used as natural insecticides.
Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum.[Pubmed:20013819]
Phytother Res. 2010 Jun;24(6):821-6.
Ten steroidal alkaloids - cyclopamine, veratramine, jervine, 3, 15-diangyloylgermine, 3-angyloylzygadenine, 3-veratroyl zygadenine, 15-veratroylgermine, germine, veratrosine and Pseudojervine - from Veratrum dahuricum, together with the ethanol extract and total alkaloids, were evaluated for their antitumor and antiplatelet activities. Cyclopamine, veratramine and germine significantly inhibited the hedgehog pathway in NIH/3T3 cells. Cyclopamine exerted a potent inhibitory effect against the growth of PANC-1 tumors in mice, with inhibition rates of 40.64%, 44.37%, 46.77% at doses of 5.0, 15.0 and 50.0 mg kg-1, respectively. Veratroylgermine was found to produce the strongest inhibition against the platelet aggregation induced by arachidonic acid, with inhibition rate of 92.0% at 100 microM.