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Pseudojervine

CAS# 36069-05-3

Pseudojervine

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Quality Control of Pseudojervine

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Chemical structure

Pseudojervine

3D structure

Chemical Properties of Pseudojervine

Cas No. 36069-05-3 SDF Download SDF
PubChem ID 16398499.0 Appearance Powder
Formula C33H49NO8 M.Wt 587.75
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyspiro[1,2,3,4,6,6a,6b,7,8,11a-decahydrobenzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-11-one
SMILES CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5C(=O)C4=C3C)C)OC7C(C(C(C(O7)CO)O)O)O)C)NC1
Standard InChIKey HYDDDNUKNMMWBD-VPLHBGEQSA-N
Standard InChI InChI=1S/C33H49NO8/c1-15-11-22-26(34-13-15)17(3)33(42-22)10-8-20-21-6-5-18-12-19(40-31-30(39)29(38)27(36)23(14-35)41-31)7-9-32(18,4)25(21)28(37)24(20)16(33)2/h5,15,17,19-23,25-27,29-31,34-36,38-39H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,22+,23+,25+,26-,27+,29-,30+,31+,32-,33-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Pseudojervine Dilution Calculator

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Pseudojervine Molarity Calculator

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Preparing Stock Solutions of Pseudojervine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7014 mL 8.507 mL 17.014 mL 34.0281 mL 42.5351 mL
5 mM 0.3403 mL 1.7014 mL 3.4028 mL 6.8056 mL 8.507 mL
10 mM 0.1701 mL 0.8507 mL 1.7014 mL 3.4028 mL 4.2535 mL
50 mM 0.034 mL 0.1701 mL 0.3403 mL 0.6806 mL 0.8507 mL
100 mM 0.017 mL 0.0851 mL 0.1701 mL 0.3403 mL 0.4254 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Pseudojervine

Exploring the hypoglycaemic efficacy of bio-accessed antioxidative polyphenolics in thermally processed Cucumis dipsaceus fruits - An in vitro and in silico study.[Pubmed:37804734]

Food Chem. 2024 Mar 1;435:137577.

Inhibition of breakdown of dietary carbohydrates, by controlling the postprandial activity of diabetic enzymes through fruit polyphenolics can help downregulate the effects of Type 2 Diabetes Mellitus (T2DM). The study focuses on deciphering the induction of hyperglycaemic control by bio-accessed anti-oxidative polyphenols of Cucumic dipsaceus fruits. Chiefly, we examined the antioxidant activity of bio-accessed polyphenols of C. dipsaceus fruits (DPPH: ME (GDE)-66.26 %; ABTS: FE (IDE)-1963.83 microM TEAC/mg extract; Phosphomolybdenum reduction: FE (IDE)- 64.95 mg AAEAC/g extract). To add more significance, the anti-diabetic activity was predetermined by in silico docking analyses (Pseudojervine - -5.43; Squalene- -10.41) and was concurrently confirmed by in vitro studies (alpha amylase inhibition: ME (GDE) - 69.58 %; alpha glucosidase inhibition: FE (UDE)- 88.67 %). A higher bio-accessibility of rutin (37.92 mg/g ODE) and gallic acid (8.36 mg/g ODE) was observed after quantification by HPLC, which confirmed the correlation between anti-diabetic activity and C. dipsaceus fruit phenolic compounds.

Quantitative determination of six steroid alkaloids by sensitive hydrophilic interaction liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic study in rats.[Pubmed:30187929]

Biomed Chromatogr. 2019 Jan;33(1):e4377.

In this study, a sensitive hydrophilic interaction liquid chromatography (HILIC) method was developed to determine Pseudojervine (PJV), veratrosine (VTS), jervine (JV), veratramine (VTM), veramarine (VA) and veratroylzygadenine (VTG) in rat plasma. Separations were carried out using LC-MS/MS with a Chrom Matrix HP amide column (5 m, 10 cm x 3.0 mm i.d.). The mobile phases were (A) 0.01 mm formic acid and (B) acetonitrile. Good linearity was found for all analytes (R(2) > 0.995) in the concentration range from 5 to 1000 mug/L with LLOQ at 5 mug/L for VTM and VTS; and from 1 to 1000 mug/L with LLOQ at 1 mug/L for PJV, JV, VA and VTG. Accuracy of the assay varied from 90.5 to 108.1%. The extraction recovery and matrix effect of six analytes ranged from 72.2 to 95.5% and from 79.2 to 98.4%. According to the stability test, six analytes in rat plasma were stable during the analysis process. On the basis of validation of the assay, the pharmacokinetics of the six steroid alkaloids were investigated after oral administration of Lilu extracts to rats.

Insecticidal metabolites from the rhizomes of Veratrum album against adults of Colorado potato beetle, Leptinotarsa decemlineata.[Pubmed:25146763]

Chem Biodivers. 2014 Aug;11(8):1192-204.

The dried rhizomes of Veratrum album were individually extracted with CHCl3 , acetone, and NH4 OH/benzene to test the toxic effects against the Colorado potato beetle, Leptinotarsa decemlineata, which is an important agricultural pest. Fifteen compounds in various amounts were isolated from the extracts using column and thin-layer chromatography. The chemical structures of 14 compounds were characterized as octacosan-1-ol (1), beta-sitosterol (2), stearic acid (3), diosgenin (4), resveratrol (5), wittifuran X (6), oxyresveratrol (7), beta-sitosterol 3-O-beta-D-glucopyranoside (8), diosgenin 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyronoside (9), oxyresveratrol 3-O-beta-D-glucopyranoside (10), jervine (11), Pseudojervine (13), 5,6-dihydro-1-hydroxyjervine (14), and saccharose (15) using UV, IR, MS, (1) H- and (13)C-NMR, and 2D-NMR spectroscopic methods. However, the chemical structure of 12, an oligosaccharide, has not fully been elucidated. Compounds 4, 6, 9, and 10 were isolated from V. album rhizomes for the first time in the current study. The toxic effects of three extracts (acetone, CHCl3 , and NH4 OH/benzene) and six metabolites, 2, 2+4, 5, 7, 8, and 11, were evaluated against the Colorado potato beetle. The assay revealed that all three extracts, and compounds 7, 8, and 11 exhibited potent toxic effects against this pest. This is the first report on the evaluation of the toxic effects of the extracts and secondary metabolites of V. album rhizomes against L. decemlineata. Based on these results, it can be concluded that the extracts can be used as natural insecticides.

Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum.[Pubmed:20013819]

Phytother Res. 2010 Jun;24(6):821-6.

Ten steroidal alkaloids - cyclopamine, veratramine, jervine, 3, 15-diangyloylgermine, 3-angyloylzygadenine, 3-veratroyl zygadenine, 15-veratroylgermine, germine, veratrosine and Pseudojervine - from Veratrum dahuricum, together with the ethanol extract and total alkaloids, were evaluated for their antitumor and antiplatelet activities. Cyclopamine, veratramine and germine significantly inhibited the hedgehog pathway in NIH/3T3 cells. Cyclopamine exerted a potent inhibitory effect against the growth of PANC-1 tumors in mice, with inhibition rates of 40.64%, 44.37%, 46.77% at doses of 5.0, 15.0 and 50.0 mg kg-1, respectively. Veratroylgermine was found to produce the strongest inhibition against the platelet aggregation induced by arachidonic acid, with inhibition rate of 92.0% at 100 microM.

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