Neural Development

Neural development describes the growth and development of the nervous system starting from embryogenesis and continuing throughout life.

Neural Development Products Targets

Products for Neural Development - Page 4

Cat.No. Product Name Information/Activity
BCC6230 Phenobarbital sodium salt 57-30-7
BCC2156 Valproic acid sodium salt (Sodium valproate) Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
BCC2512 Zonisamide Zonisamide is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.
BCC3940 AY 9944 dihydrochloride AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol.
BCC3939 Ciliobrevin A Ciliobrevin A is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM.
BCN2964 Cyclopamine Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay.
BCC1587 GANT 58 GANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM.
BCC1090 GANT61 GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.
BCC3938 HPI 1 Inhibits Hedgehog signaling
BCC3936 JK 184 JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.