Glutamate (EAAT) Transporters - Membrane Transporter/Ion Channel

Cat.No. Product Name Information

BCC7692 UCPH 101 UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM.

BCC6608 L-CCG-lll

BCC7757 7-Chlorokynurenic acid sodium salt 7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery.

BCC6873 MPDC MPDC is a potent and competitive inhibitor of the Na+-dependent high-affinity glutamate transporter in forebrain synaptosomes. MPDC

BCC6577 7-Chlorokynurenic acid 7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery.

BCC5735 DL-TBOA DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively. DL-TBOA

BCC7294 (±)-HIP-A

BCC7295 (±)-HIP-B

BCC6815 Evans Blue tetrasodium salt Selective P2X purinergic antagonist,Evans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).

BCC5919 TFB-TBOA

BCC6556 Dihydrokainic acid

BCC8023 Congo Red Congo red is an azo dye.

BCC6804 (±)-threo-3-Methylglutamic acid

BCC8024 Rose Bengal Potent VGlut and VMAT inhibitor; cell permeable

BCC6595 L-trans-2,4-PDC

BCC6565 L-(-)-threo-3-Hydroxyaspartic acid

BCC6587 cis-ACBD

BCC7442 WAY 213613 WAY-213613 is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC50 of 85 nM EAAT2. It displays 59- and 44-fold selectivity over EAAT1 and EAAT3 (IC50s are 5 and 3.8 μM, respectively). WAY-213613 shows no activity at ionotropic and metabotropic glutamate receptors. It is a potential tool for the elucidation of EAAT2 function. WAY 213613

BCC6361 LDN 212320 LDN-212320(OSU-0212320) is a glutamate transporter EAAT2 activator; enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.

Products for Glutamate (EAAT) Transporters