Glutamate (EAAT) Transporters
Glutamate transporters are a family of neurotransmitter transporter proteins that move glutamate – the principal excitatory neurotransmitter – across a membrane. The family of glutamate transporters is composed of two primary subclasses: the excitatory amino acid transporter (EAAT) family and vesicular glutamate transporter (VGLUT) family. In the brain, EAATs remove glutamate from the synaptic cleft and extrasynaptic sites via glutamate reuptake into glial cells and neurons, while VGLUTs move glutamate from the cell cytoplasm into synaptic vesicles. Glutamate transporters also transport aspartate and are present in virtually all peripheral tissues, including the heart, liver, testes, and bone. They exhibit stereoselectivity for L-glutamate but transport both L-aspartate and D-aspartate.
Products for Glutamate (EAAT) Transporters
- Cat.No. Product Name Information
- BCC5735 DL-TBOASelective non-transportable inhibitor of EAATs
- BCC5919 TFB-TBOAHigh affinity EAAT1 and EAAT2 blocker
- BCC6361 LDN 212320
- BCC6556 Dihydrokainic acidEAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake
- BCC6565 L-(-)-threo-3-Hydroxyaspartic acidTransportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
- BCC6577 7-Chlorokynurenic acidPotent competitive inhibitor of L-glutamate uptake
- BCC6587 cis-ACBDPotent, selective L-glutamate uptake inhibitor
- BCC6595 L-trans-2,4-PDCTransportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
- BCC6608 L-CCG-lllPotent, competitive glutamate uptake inhibitor
- BCC6804 (±)-threo-3-Methylglutamic acidEAAT2 and EAAT4 blocker
- BCC6815 Evans Blue tetrasodium saltSelective P2X purinergic antagonist
- BCC6873 MPDC
- BCC7294 (±)-HIP-A
- BCC7295 (±)-HIP-BPotent, non-competitive EAAT inhibitor
- BCC7442 WAY 213613Potent, non-substrate EAAT2 inhibitor
- BCC7692 UCPH 101Selective non-substrate EAAT1 inhibitor
- BCC7757 7-Chlorokynurenic acid sodium salt
- BCC8023 Congo Red
- BCC8024 Rose BengalPotent VGlut and VMAT inhibitor; cell permeable