Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC6648 | Etazolate hydrochloride |
| Phosphodiesterase inhibitor, selective for PDE4 (IC50 = 2.0 μM). | |
| BCC6663 | Alrestatin |
| Specific inhibitor of aldose reductase (IC50 = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro. | |
| BCC6665 | (±)-U-50488 hydrochloride |
| Selective κ-opioid agonist. At higher concentrations blocks Na+ channels. Separate isomers (+)-U-50488 and (-)-U-50488 also available . | |
| BCC6667 | AG 99 |
| Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 10 μM) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro. | |
| BCC6668 | U-54494A hydrochloride |
| κ-opioid agonist and anticonvulsant. Perhaps acts as an NMDA antagonist. | |
| BCC6669 | N1,N12-Diethylspermine tetrahydrochloride |
| Powerful antineoplastic agent in cultured cells and animal tumors (IC50 = 0.2 μM in L1210 cells). Inhibitor of polyamine synthases. Suppressor of mitochondrial DNA synthesis. | |
| BCC6670 | Diphenyleneiodonium chloride |
| GPR3 agonist (EC50 = 1 μM); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca2+ mobilization and β-arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation. | |
| BCC6671 | Dihydroergotoxine mesylate |
| A complex of closely related alkaloid salts. Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. Also interacts with central dopaminergic, serotonergic and adrenergic (α1) receptors. Displays antiproliferative activity in vitro (IC50 = 18 - 38 μM in prostate cancer cells) and exhibits cognition-enhancing, anticonvulsant and sedative activity in vivo. Orally active. | |
