2-(3,4-Dihydroxyphenyl)ethanolCAS# 10597-60-1 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 10597-60-1 | SDF | Download SDF |
| PubChem ID | 82755 | Appearance | Colorless liquid |
| Formula | C8H10O3 | M.Wt | 154.2 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Synonyms | 3,4-Dihydroxyphenethyl alcohol; Homoprotocatechuyl alcohol | ||
| Solubility | Soluble in methan | ||
| Chemical Name | 4-(2-hydroxyethyl)benzene-1,2-diol | ||
| SMILES | C1=CC(=C(C=C1CCO)O)O | ||
| Standard InChIKey | JUUBCHWRXWPFFH-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 2-(3,4-Dihydroxyphenyl)ethanol has antioxidant properties; it is a potent specific inhibitor of lipoxygenase activities, it inhibits platelet 12-LO activity (IC50, 4.2 microM) and PMNL 5-LO activity (IC50, 13 microM) but not cyclooxygenase activity in cell-free conditions; it also inhibits 12-LO activity in intact platelets (IC50, 50 microM) and reduces leukotriene B4 production in intact PMNL stimulated by A23187 (IC50, 26 microM). |
| Targets | Immunology & Inflammation related | SOD | CAT |
| In vivo | Antioxidant role of hydroxytyrosol on oxidative stress in cadmium-intoxicated rats: different effect in spleen and testes.[Pubmed: 24437686 ]Drug Chem Toxicol. 2014 Oct;37(4):420-6.Hydroxytyrosol (2-(3,4-Dihydroxyphenyl)ethanol, (DPE), a phenolic compound present in olive oil, is known to have antioxidant properties. |
| Kinase Assay | Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives.[Pubmed: 9058975]Biosci Biotechnol Biochem. 1997 Feb;61(2):347-50.
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2-(3,4-Dihydroxyphenyl)ethanol Dilution Calculator
2-(3,4-Dihydroxyphenyl)ethanol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.4851 mL | 32.4254 mL | 64.8508 mL | 129.7017 mL | 162.1271 mL |
| 5 mM | 1.297 mL | 6.4851 mL | 12.9702 mL | 25.9403 mL | 32.4254 mL |
| 10 mM | 0.6485 mL | 3.2425 mL | 6.4851 mL | 12.9702 mL | 16.2127 mL |
| 50 mM | 0.1297 mL | 0.6485 mL | 1.297 mL | 2.594 mL | 3.2425 mL |
| 100 mM | 0.0649 mL | 0.3243 mL | 0.6485 mL | 1.297 mL | 1.6213 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives.[Pubmed:9058975]
Biosci Biotechnol Biochem. 1997 Feb;61(2):347-50.
The effects of olive fruit extract on arachidonic acid lipoxygenase activities were investigated using rat platelets and rat polymorphonuclear leukocytes (PMNL). Olive extract strongly inhibited both 12-lipoxygenase (12-LO) and 5-lipoxygenase (5-LO) activities. One of the compounds responsible for this inhibition was purified and identified as 2-(3,4-Dihydroxyphenyl)ethanol (DPE). DPE inhibited platelet 12-LO activity (IC50, 4.2 microM) and PMNL 5-LO activity (IC50, 13 microM) but not cyclooxygenase activity in cell-free conditions. It also inhibited 12-LO activity in intact platelets (IC50, 50 microM) and reduced leukotriene B4 production in intact PMNL stimulated by A23187 (IC50, 26 microM). The inhibition by DPE of both lipoxygenase activities was stronger than that by oleuropein, caffeic acid, or 7 other related phenolic compounds, especially in intact cells. These results suggest that DPE is a potent specific inhibitor of lipoxygenase activities.
