Abiesadine I

CAS# 1210347-50-4

Abiesadine I

2D Structure

Catalog No. BCN6104----Order now to get a substantial discount!

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Abiesadine I: 5mg Please Inquire In Stock
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Quality Control of Abiesadine I

3D structure

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Abiesadine I

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Chemical Properties of Abiesadine I

Cas No. 1210347-50-4 SDF Download SDF
PubChem ID 46230076 Appearance Powder
Formula C24H34O5 M.Wt 402.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-[[(1R,4aS,10aR)-7-(2-hydroxypropan-2-yl)-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methoxy]-4-oxobutanoic acid
SMILES CC1(CCCC2(C1CCC3=C2C=CC(=C3)C(C)(C)O)C)COC(=O)CCC(=O)O
Standard InChIKey POEUPUDPIRTZJS-WDJPJFJCSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Abiesadine I

The herbs of Pinus yunnanensis

Biological Activity of Abiesadine I

In vitro

Isolation, structure, and bioactivities of abiesadines A–Y, 25 new diterpenes from Abies georgei Orr[Reference: WebLink]

Bioorganic & medicinal chemistry, 2010, 18(2):744-754.


METHODS AND RESULTS:
Twenty-five new (abiesadines A–Y, Abiesadine I, 1–25, ) and 29 known (26–54) diterpenes were isolated from the aerial parts of Abies georgei. Abiesadine A (1) is a novel 8,14-seco-abietane, while abiesadine B (2) is a novel 9,10-seco-abietane. The structures of the new compounds were established on the basis of spectroscopic data analysis. Manool (52) showed the strongest effect against LPS-induced NO production in RAW264.7 macrophages with the IC50 value of 11.0 μg/mL. In another anti-inflammatory assay against TNFα-triggered NF-κB activity, (12R,13R)-8,12-epoxy-14-labden-13-ol (54) exhibited the strongest effect (IC50 = 8.7 μg/mL).
CONCLUSIONS:
For antitumor assays, pomiferin A (26) and 8,11,13-abietatriene-7α,18-diol (29) both showed the most significant activity against LOVO cells (IC50 = 9.2 μg/mL). While 7-oxocallitrisic acid (46) exhibited significant cytotoxicity against QGY-7703 tumor cells (IC50 = 10.2 μg/mL).

Abiesadine I Dilution Calculator

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Abiesadine I Molarity Calculator

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Preparing Stock Solutions of Abiesadine I

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4845 mL 12.4224 mL 24.8447 mL 49.6894 mL 62.1118 mL
5 mM 0.4969 mL 2.4845 mL 4.9689 mL 9.9379 mL 12.4224 mL
10 mM 0.2484 mL 1.2422 mL 2.4845 mL 4.9689 mL 6.2112 mL
50 mM 0.0497 mL 0.2484 mL 0.4969 mL 0.9938 mL 1.2422 mL
100 mM 0.0248 mL 0.1242 mL 0.2484 mL 0.4969 mL 0.6211 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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