N-Acetyl-5-HydroxytryptamineCAS# 1210-83-9 |
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3D structure
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| Cas No. | 1210-83-9 | SDF | Download SDF |
| PubChem ID | 903 | Appearance | Powder |
| Formula | C12H14N2O2 | M.Wt | 218.3 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 250 mg/mL (1145.48 mM; Need ultrasonic) | ||
| Chemical Name | N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide | ||
| SMILES | CC(=O)NCCC1=CNC2=C1C=C(C=C2)O | ||
| Standard InChIKey | MVAWJSIDNICKHF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
N-Acetyl-5-Hydroxytryptamine Dilution Calculator
N-Acetyl-5-Hydroxytryptamine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.5809 mL | 22.9043 mL | 45.8085 mL | 91.617 mL | 114.5213 mL |
| 5 mM | 0.9162 mL | 4.5809 mL | 9.1617 mL | 18.3234 mL | 22.9043 mL |
| 10 mM | 0.4581 mL | 2.2904 mL | 4.5809 mL | 9.1617 mL | 11.4521 mL |
| 50 mM | 0.0916 mL | 0.4581 mL | 0.9162 mL | 1.8323 mL | 2.2904 mL |
| 100 mM | 0.0458 mL | 0.229 mL | 0.4581 mL | 0.9162 mL | 1.1452 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Catecholamine and Indolamine Pathway: A Case-Control Study in Fibromyalgia.[Pubmed:30009619]
Biol Res Nurs. 2018 Oct;20(5):577-586.
OBJECTIVES: Fibromyalgia (FM) is a complex syndrome characterized by widespread pain. Its etiology is unclear, and diagnosis is difficult. The aim of this study was to assess plasma levels of monoamine neurotransmitters (catecholamines, indolamines, and intermediate metabolites) in patients with FM and healthy controls to investigate possible alterations in the metabolism of these molecules in FM. We also examined potential relationships between monoamine neurotransmitters and clinical features of FM. The predictive value of these molecules in FM was determined by receiver operating characteristic analysis. METHOD: We measured plasma catecholamines (epinephrine, norepinephrine, and dopamine), as well as indolamines and intermediary metabolites (serotonin or 5-hydroxytryptamine [5-HT], 5-hydroxyindolacetic acid [5-HIAA], 5-hydroxytryptophan [5-HTP], and N-Acetyl-5-Hydroxytryptamine [Nac-5-HT]) in 35 women with FM and 12 age-matched healthy women. RESULTS: Higher levels of norepinephrine and lower levels of dopamine, 5-HT, 5-HIAA, and 5-HTP were found in women with FM in comparison with controls. Epinephrine and Nac-5-HT levels did not differ significantly between groups. Higher norepinephrine levels were associated with worse physical health status in FM patients. Also, plasma norepinephrine levels > 694.69 pg/ml might be an accurate predictor of FM. CONCLUSIONS: These findings show evidence of the dysregulation of the catecholamine and indolamine pathway in patients with FM, which may contribute to the physiopathology of this syndrome. In addition, the determination of plasma norepinephrine levels could help in the FM diagnosis.
