Cl-HOBt

CAS# 26198-19-6

Cl-HOBt

Catalog No. BCC2829----Order now to get a substantial discount!

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Cl-HOBt: 5mg $6 In Stock
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Chemical structure

Cl-HOBt

3D structure

Chemical Properties of Cl-HOBt

Cas No. 26198-19-6 SDF Download SDF
PubChem ID 232711 Appearance Powder
Formula C6H4ClN3O M.Wt 169.6
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 6-chloro-1-hydroxybenzotriazole
SMILES C1=CC2=C(C=C1Cl)N(N=N2)O
Standard InChIKey TZCYLJGNWDVJRA-UHFFFAOYSA-N
Standard InChI InChI=1S/C6H4ClN3O/c7-4-1-2-5-6(3-4)10(11)9-8-5/h1-3,11H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Cl-HOBt Dilution Calculator

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Cl-HOBt Molarity Calculator

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Preparing Stock Solutions of Cl-HOBt

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.8962 mL 29.4811 mL 58.9623 mL 117.9245 mL 147.4057 mL
5 mM 1.1792 mL 5.8962 mL 11.7925 mL 23.5849 mL 29.4811 mL
10 mM 0.5896 mL 2.9481 mL 5.8962 mL 11.7925 mL 14.7406 mL
50 mM 0.1179 mL 0.5896 mL 1.1792 mL 2.3585 mL 2.9481 mL
100 mM 0.059 mL 0.2948 mL 0.5896 mL 1.1792 mL 1.4741 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Cl-HOBt

Reagent to suppress racemization in peptide coupling, which is not toxic.

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References on Cl-HOBt

Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors.[Pubmed:23890524]

Bioorg Med Chem. 2013 Sep 1;21(17):5029-38.

Probes for use in time-resolved fluorescence competitive binding assays at melanocortin receptors based on the parental ligands MSH(4), MSH(7), and NDP-alpha-MSH were prepared by solid phase synthesis methods, purified, and characterized. The saturation binding of these probes was studied using HEK-293 cells engineered to overexpress the human melanocortin 4 receptor (hMC4R) as well as the human cholecystokinin 2 receptor (hCCK2R). The ratios of non-specific binding to total binding approached unity at high concentrations for each probe. At low probe concentrations, receptor-mediated binding and uptake was discernable, and so probe concentrations were kept as low as possible in determining Kd values. The Eu-DTPA-PEGO-MSH(4) probe exhibited low specific binding relative to non-specific binding, even at low nanomolar concentrations, and was deemed unsuitable for use in competition binding assays. The Eu-DTPA-PEGO probes based on MSH(7) and NDP-alpha-MSH exhibited Kd values of 27+/-3.9nM and 4.2+/-0.48nM, respectively, for binding with hMC4R. These probes were employed in competitive binding assays to characterize the interactions of hMC4R with monovalent and divalent MSH(4), MSH(7), and NDP-alpha-MSH constructs derived from squalene. Results from assays with both probes reflected only statistical enhancements, suggesting improper ligand spacing on the squalene scaffold for the divalent constructs. The Ki values from competitive binding assays that employed the MSH(7)-based probe were generally lower than the Ki values obtained when the probe based on NDP-alpha-MSH was employed, which is consistent with the greater potency of the latter probe. The probe based on MSH(7) was also competed with monovalent, divalent, and trivalent MSH(4) constructs that previously demonstrated multivalent binding in competitive binding assays against a variant of the probe based on NDP-alpha-MSH. Results from these assays confirm multivalent binding, but suggest a more modest increase in avidity for these MSH(4) constructs than was previously reported.

N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile.[Pubmed:23932788]

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5082-5.

Derivatives of peptides of the TIPP (Tyr-Tic-Phe-Phe; Tic=1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) family containing a guanidino (Guan) function in place of the N-terminal amino group were synthesized in an effort to improve their blood-brain barrier permeability. Unexpectedly, N-terminal amidination significantly altered the in vitro opioid activity profiles. Guan-analogues of TIPP-related delta opioid antagonists showed delta partial agonist or mixed delta partial agonist/mu partial agonist activity. Guanidinylation of the mixed mu agonist/delta antagonists H-Dmt-Tic-Phe-Phe-NH2 (DIPP-NH2) and H-Dmt-TicPsi[CH2NH]Phe-Phe-NH2 (DIPP-NH2[Psi]) converted them to mixed mu agonist/delta agonists. A docking study revealed distinct positioning of DIPP-NH2 and Guan-DIPP-NH2 in the delta receptor binding site. Lys(3)-analogues of DIPP-NH2 and DIPP-NH2[Psi] (guanidinylated or non-guanidinylated) turned out to be mixed mu/kappa agonists with delta antagonist-, delta partial agonist- or delta full agonist activity. Compounds with some of the observed mixed opioid activity profiles have therapeutic potential as analgesics with reduced side effects or for treatment of cocaine addiction.

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