Fmoc-Hyp(tBu)-OHCAS# 122996-47-8 |
- PF-4708671
Catalog No.:BCC5031
CAS No.:1255517-76-0
- BIX 02565
Catalog No.:BCC4303
CAS No.:1311367-27-7
- BI-D1870
Catalog No.:BCC5030
CAS No.:501437-28-1
- CMK
Catalog No.:BCC1489
CAS No.:821794-90-5
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 122996-47-8 | SDF | Download SDF |
PubChem ID | 978347 | Appearance | Powder |
Formula | C24H27NO5 | M.Wt | 409.5 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | (2S,4R)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxy]pyrrolidine-2-carboxylic acid | ||
SMILES | CC(C)(C)OC1CC(N(C1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)O | ||
Standard InChIKey | WPBXBYOKQUEIDW-VFNWGFHPSA-N | ||
Standard InChI | InChI=1S/C24H27NO5/c1-24(2,3)30-15-12-21(22(26)27)25(13-15)23(28)29-14-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,15,20-21H,12-14H2,1-3H3,(H,26,27)/t15-,21+/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Fmoc-Hyp(tBu)-OH Dilution Calculator
Fmoc-Hyp(tBu)-OH Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.442 mL | 12.21 mL | 24.42 mL | 48.84 mL | 61.0501 mL |
5 mM | 0.4884 mL | 2.442 mL | 4.884 mL | 9.768 mL | 12.21 mL |
10 mM | 0.2442 mL | 1.221 mL | 2.442 mL | 4.884 mL | 6.105 mL |
50 mM | 0.0488 mL | 0.2442 mL | 0.4884 mL | 0.9768 mL | 1.221 mL |
100 mM | 0.0244 mL | 0.1221 mL | 0.2442 mL | 0.4884 mL | 0.6105 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Fmoc-Hyp(tBu)-OH
- RG7388
Catalog No.:BCC1895
CAS No.:1229705-06-9
- HA 130
Catalog No.:BCC7884
CAS No.:1229652-21-4
- 6'-O-Galloyl paeoniflorin
Catalog No.:BCN2941
CAS No.:122965-41-7
- URMC-099
Catalog No.:BCC5563
CAS No.:1229582-33-5
- XE 991 dihydrochloride
Catalog No.:BCC7232
CAS No.:122955-13-9
- N-(3-Methoxybenzyl)palmitamide
Catalog No.:BCN8086
CAS No.:847361-96-0
- Fmoc-L-Beta-Homoproline
Catalog No.:BCN8087
CAS No.:193693-60-6
- LY2784544
Catalog No.:BCC2200
CAS No.:1229236-86-5
- C 21
Catalog No.:BCC8013
CAS No.:1229236-78-5
- GS-9973
Catalog No.:BCC5278
CAS No.:1229208-44-9
- Edoxaban tosylate monohydrate
Catalog No.:BCC1545
CAS No.:1229194-11-9
- 3-O-Acetylandrostenone hydrazone
Catalog No.:BCC8637
CAS No.:122914-94-7
- 4-Hydroxybenzaldehyde
Catalog No.:BCN5816
CAS No.:123-08-0
- Anisic aldehyde
Catalog No.:BCN2618
CAS No.:123-11-5
- D-erythro-Sphingosine (synthetic)
Catalog No.:BCC6729
CAS No.:123-78-4
- Azelaic Acid
Catalog No.:BCC8300
CAS No.:123-99-9
- Azasetron HCl
Catalog No.:BCC5035
CAS No.:123040-16-4
- Bulleyanin
Catalog No.:BCN6120
CAS No.:123043-54-9
- Phyltetralin
Catalog No.:BCN3051
CAS No.:123048-17-9
- BAF312 (Siponimod)
Catalog No.:BCC5114
CAS No.:1230487-00-9
- 4,8-Dihydroxyeudesm-7(11)-en-12,8-olide
Catalog No.:BCN1600
CAS No.:1231208-53-9
- Uncaric acid
Catalog No.:BCN6121
CAS No.:123135-05-7
- Cefepime Dihydrochloride Monohydrate
Catalog No.:BCC5261
CAS No.:123171-59-5
- LY2835219 free base
Catalog No.:BCC1722
CAS No.:1231929-97-7
A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile--the pharmacological importance of post-translational modifications.[Pubmed:24055806]
Peptides. 2013 Nov;49:145-58.
Cone snail venoms provide a largely untapped source of novel peptide drug leads. To enhance the discovery phase, a detailed comparative proteomic analysis was undertaken on milked venom from the mollusk-hunting cone snail, Conus textile, from three different geographic locations (Hawai'i, American Samoa and Australia's Great Barrier Reef). A novel milked venom conopeptide rich in post-translational modifications was discovered, characterized and named alpha-conotoxin TxIC. We assign this conopeptide to the 4/7 alpha-conotoxin family based on the peptide's sequence homology and cDNA pre-propeptide alignment. Pharmacologically, alpha-conotoxin TxIC demonstrates minimal activity on human acetylcholine receptor models (100 muM, <5% inhibition), compared to its high paralytic potency in invertebrates, PD50 = 34.2 nMol kg(-1). The non-post-translationally modified form, [Pro](2,8)[Glu](16)alpha-conotoxin TxIC, demonstrates differential selectivity for the alpha3beta2 isoform of the nicotinic acetylcholine receptor with maximal inhibition of 96% and an observed IC50 of 5.4 +/- 0.5 muM. Interestingly its comparative PD50 (3.6 muMol kg(-1)) in invertebrates was ~100 fold more than that of the native peptide. Differentiating alpha-conotoxin TxIC from other alpha-conotoxins is the high degree of post-translational modification (44% of residues). This includes the incorporation of gamma-carboxyglutamic acid, two moieties of 4-trans hydroxyproline, two disulfide bond linkages, and C-terminal amidation. These findings expand upon the known chemical diversity of alpha-conotoxins and illustrate a potential driver of toxin phyla-selectivity within Conus.