H-DL-Phe(4-Cl)-OMe.HCl

Tryptophan hydroxylase inhibitor CAS# 14173-40-1

H-DL-Phe(4-Cl)-OMe.HCl

Catalog No. BCC3175----Order now to get a substantial discount!

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H-DL-Phe(4-Cl)-OMe.HCl: 5mg $6 In Stock
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Chemical structure

H-DL-Phe(4-Cl)-OMe.HCl

3D structure

Chemical Properties of H-DL-Phe(4-Cl)-OMe.HCl

Cas No. 14173-40-1 SDF Download SDF
PubChem ID 2733277 Appearance Powder
Formula C10H13Cl2NO2 M.Wt 250.1
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in water and to 100 mM in DMSO
Chemical Name 4-Chloro-DL-Phenylalanine methyl ester hydrochloride
SMILES [Cl-].COC(=O)C([NH3+])Cc1ccc(Cl)cc1
Standard InChIKey GCBCWTWQAFLKJG-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of H-DL-Phe(4-Cl)-OMe.HCl

DescriptionTryptophan hydroxylase inhibitor. Inhibits 5-HT synthesis. Depletes 5-HT levels in orbitofrontal cortex and impairs reversal learning in rats. Methyl ester of p-Chlorophenylalanine.

H-DL-Phe(4-Cl)-OMe.HCl Dilution Calculator

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H-DL-Phe(4-Cl)-OMe.HCl Molarity Calculator

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Preparing Stock Solutions of H-DL-Phe(4-Cl)-OMe.HCl

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9984 mL 19.992 mL 39.984 mL 79.968 mL 99.96 mL
5 mM 0.7997 mL 3.9984 mL 7.9968 mL 15.9936 mL 19.992 mL
10 mM 0.3998 mL 1.9992 mL 3.9984 mL 7.9968 mL 9.996 mL
50 mM 0.08 mL 0.3998 mL 0.7997 mL 1.5994 mL 1.9992 mL
100 mM 0.04 mL 0.1999 mL 0.3998 mL 0.7997 mL 0.9996 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on H-DL-Phe(4-Cl)-OMe.HCl

Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test.[Pubmed:26596986]

Prog Neuropsychopharmacol Biol Psychiatry. 2016 Feb 4;65:201-7.

Depression is one of the most commonly diagnosed neuropsychiatric disorders and several studies have demonstrated a role for selenium in mood disorders. For this reason, the present study investigated the role of the monoaminergic system in the antidepressant-like action of (octylseleno)-xylofuranoside (OSX), an organoselenium compound, in the tail suspension test (TST) in mice. For this purpose, OSX (0.001-10 mg/kg) was administered orally (p.o.) 30 min prior to testing, and all of the tested doses reduced the immobility time in the TST without changing the locomotor activity measured in the open field test (OFT). Furthermore, the antidepressant-like effect of OSX (0.01 mg/kg, p.o.) in the TSTwas prevented by pre-treatment in mice with ketanserin (1 mg/kg, intraperitoneal route (i.p.); a 5-HT2A/2C receptor antagonist),WAY100635 (0.1mg/kg, subcutaneous (s.c.); a selective 5-HT1A receptor antagonist), p-chlorophenylalaninemethyl ester-PCPA (100mg/kg, i.p.; a selective inhibitor of tryptophan hydroxylase), prazosin (1 mg/kg, i.p.; an alpha1-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p.; an alpha2-adrenoceptor antagonist), SCH233390 (0.05 mg/kg, s.c., a dopaminergic D1 receptor antagonist) and sulpiride (50 mg/kg, i.p., a dopaminergic D2 receptor antagonist), but not with ondansetron (1 mg/kg, i.p.; a selective 5-HT3 receptor antagonist). Taken together, these data demonstrate that OSX has a potent antidepressant like effect in TST at lower doses (0.001-10 mg/kg), which is dependent on its interaction with the serotonergic, noradrenergic and dopaminergic systems.

Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats.[Pubmed:24852131]

Int J Neuropsychopharmacol. 2014 Oct;17(10):1695-706.

Current treatments for depression, including serotonin-specific reuptake inhibitors (SSRIs), are only partially effective, with a high incidence of residual symptoms, relapse, and treatment resistance. Loss of cognitive flexibility, a component of depression, is associated with dysregulation of the prefrontal cortex. Reversal learning, a form of cognitive flexibility, is impaired by chronic stress, a risk factor for depression, and the stress-induced impairment in reversal learning is sensitive to chronic SSRI treatment, and is mimicked by serotonin (5-HT) depletion. Vortioxetine, a novel, multimodal-acting antidepressant, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist, and inhibits the 5-HT transporter. Using adult male rats, we first investigated the direct effects of vortioxetine, acting at post-synaptic 5-HT receptors, on reversal learning that was compromised by 5-HT depletion using 4-chloro-DL-phenylalanine methyl ester hydrochloride (PCPA), effectively eliminating any contribution of 5-HT reuptake blockade. PCPA induced a reversal learning impairment that was alleviated by acute or sub-chronic vortioxetine administration, suggesting that post-synaptic 5-HT receptor activation contributes to the effects of vortioxetine. We then investigated the effects of chronic dietary administration of vortioxetine on reversal learning that had been compromised in intact animals exposed to chronic intermittent cold (CIC) stress, to assess vortioxetine's total pharmacological effect. CIC stress impaired reversal learning, and chronic vortioxetine administration prevented the reversal-learning deficit. Together, these results suggest that the direct effect of vortioxetine at 5-HT receptors may contribute to positive effects on cognitive flexibility deficits, and may enhance the effect of 5-HT reuptake blockade.

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