QL47BTK kinase inhibitor CAS# 1469988-75-7 |
2D Structure
- AVL-292
Catalog No.:BCC1385
CAS No.:1202757-89-8
- RN486
Catalog No.:BCC3921
CAS No.:1242156-23-5
- PCI 29732
Catalog No.:BCC4100
CAS No.:330786-25-9
- CGI-1746
Catalog No.:BCC1473
CAS No.:910232-84-7
- PCI-32765 (Ibrutinib)
Catalog No.:BCC1266
CAS No.:936563-96-1
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
Cas No. | 1469988-75-7 | SDF | Download SDF |
PubChem ID | 71748056 | Appearance | Powder |
Formula | C27H21N5O2 | M.Wt | 447.49 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Synonyms | BTK Inhibitor | ||
Solubility | DMSO : < 1 mg/mL (insoluble or slightly soluble) | ||
Chemical Name | 9-(1-methylpyrazol-4-yl)-1-(1-prop-2-enoyl-2,3-dihydroindol-6-yl)benzo[h][1,6]naphthyridin-2-one | ||
SMILES | CN1C=C(C=N1)C2=CC3=C4C(=CN=C3C=C2)C=CC(=O)N4C5=CC6=C(CCN6C(=O)C=C)C=C5 | ||
Standard InChIKey | RTRNJQOBEOISFQ-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C27H21N5O2/c1-3-25(33)31-11-10-17-4-7-21(13-24(17)31)32-26(34)9-6-19-14-28-23-8-5-18(12-22(23)27(19)32)20-15-29-30(2)16-20/h3-9,12-16H,1,10-11H2,2H3 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM.
IC50 Value: 7 nM
Target: Btk
in vitro: QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations [1].
in vivo: N/A References: |
QL47 Dilution Calculator
QL47 Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.2347 mL | 11.1734 mL | 22.3469 mL | 44.6937 mL | 55.8672 mL |
5 mM | 0.4469 mL | 2.2347 mL | 4.4694 mL | 8.9387 mL | 11.1734 mL |
10 mM | 0.2235 mL | 1.1173 mL | 2.2347 mL | 4.4694 mL | 5.5867 mL |
50 mM | 0.0447 mL | 0.2235 mL | 0.4469 mL | 0.8939 mL | 1.1173 mL |
100 mM | 0.0223 mL | 0.1117 mL | 0.2235 mL | 0.4469 mL | 0.5587 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces
- Atglistatin
Catalog No.:BCC5104
CAS No.:1469924-27-3
- Y-27632 dihydrochloride
Catalog No.:BCC1273
CAS No.:129830-38-2
- Y-27632
Catalog No.:BCC4301
CAS No.:146986-50-7
- Fmoc-Lys(Aloc)-OH
Catalog No.:BCC3515
CAS No.:146982-27-6
- Fmoc-Asp(OAll)-OH
Catalog No.:BCC3089
CAS No.:146982-24-3
- Codaphniphylline
Catalog No.:BCN1652
CAS No.:14694-15-6
- Ziprasidone
Catalog No.:BCC2071
CAS No.:146939-27-7
- K-Ras(G12C) inhibitor 12
Catalog No.:BCC5562
CAS No.:1469337-95-8
- K-Ras(G12C) inhibitor 9
Catalog No.:BCC6500
CAS No.:1469337-91-4
- 1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran
Catalog No.:BCN7691
CAS No.:146905-24-0
- Triptobenzene H
Catalog No.:BCN6784
CAS No.:146900-55-2
- 1,5-Dihydroxyxanthone
Catalog No.:BCN7423
CAS No.:14686-65-8
- Diphenhydramine hydrochloride
Catalog No.:BCC8947
CAS No.:147-24-0
- DL-Arabinose
Catalog No.:BCN8541
CAS No.:147-81-9
- Proline
Catalog No.:BCN1656
CAS No.:147-85-3
- Cytarabine
Catalog No.:BCC3759
CAS No.:147-94-4
- 3'-O-Demethylarctigenin
Catalog No.:BCN3544
CAS No.:147022-95-5
- Menthyl-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid
Catalog No.:BCC9019
CAS No.:147027-10-9
- MK591
Catalog No.:BCC1766
CAS No.:147030-01-1
- Cyclo(Phe-Pro)
Catalog No.:BCN2416
CAS No.:14705-60-3
- Rocaglaol
Catalog No.:BCN1653
CAS No.:147059-46-9
- Trovafloxacin mesylate
Catalog No.:BCC3931
CAS No.:147059-75-4
- Alcaftadine
Catalog No.:BCC5260
CAS No.:147084-10-4
- 5,6-Dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-one
Catalog No.:BCC8722
CAS No.:147086-79-1
Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent.[Pubmed:28337328]
ACS Med Chem Lett. 2017 Feb 3;8(3):344-349.
Here we report the structure-activity relationship (SAR) investigations of QL-XII-47 (QL47), a compound that possesses broad-spectrum antiviral activity against dengue virus and other RNA viruses. A medicinal chemistry campaign initiated from QL47, a previously reported covalent BTK inhibitor, to derive YKL-04-085, which is devoid of any kinase activity when screened against a panel of 468 kinases and with improved pharmacokinetic properties. Both QL47 and YKL-04-085 are potent inhibitors of viral translation and exhibit cellular antiviral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation.