SolanesolCAS# 13190-97-1 |
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Number of papers citing our products
| Cas No. | 13190-97-1 | SDF | Download SDF |
| PubChem ID | 5477212 | Appearance | Powder |
| Formula | C45H74O | M.Wt | 631.07 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-ol | ||
| SMILES | CC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCO)C)C)C)C)C)C)C)C)C | ||
| Standard InChIKey | AFPLNGZPBSKHHQ-MEGGAXOGSA-N | ||
| Standard InChI | InChI=1S/C45H74O/c1-37(2)19-11-20-38(3)21-12-22-39(4)23-13-24-40(5)25-14-26-41(6)27-15-28-42(7)29-16-30-43(8)31-17-32-44(9)33-18-34-45(10)35-36-46/h19,21,23,25,27,29,31,33,35,46H,11-18,20,22,24,26,28,30,32,34,36H2,1-10H3/b38-21+,39-23+,40-25+,41-27+,42-29+,43-31+,44-33+,45-35+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Solanesol can effectively scavenge lipid radicals to block lipid peroxidation, and inhibit effects on tyrosinase; it also can protect ethanol-induced L02 cell damage, which might be attributed to the activation of HO-1 and Hsp70. |
| Targets | HSP (e.g. HSP90) | HO-1 | Caspase | PARP |
| In vitro | Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70.[Pubmed: 25645596]Toxicol In Vitro. 2015 Apr;29(3):600-8.
Antioxidant function of solanesol and its inhibitory effect on tyrosinase[Pubmed: 25464797]Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Aug;31(4):833-6, 841.The present paper intends to discuss the antioxidant and tyrosinase inhibition effect of Solanesol from three aspects of ultraviolet radiation and free radical scavenging. |
Solanesol Dilution Calculator
Solanesol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5846 mL | 7.9231 mL | 15.8461 mL | 31.6922 mL | 39.6153 mL |
| 5 mM | 0.3169 mL | 1.5846 mL | 3.1692 mL | 6.3384 mL | 7.9231 mL |
| 10 mM | 0.1585 mL | 0.7923 mL | 1.5846 mL | 3.1692 mL | 3.9615 mL |
| 50 mM | 0.0317 mL | 0.1585 mL | 0.3169 mL | 0.6338 mL | 0.7923 mL |
| 100 mM | 0.0158 mL | 0.0792 mL | 0.1585 mL | 0.3169 mL | 0.3962 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Antioxidant function of solanesol and its inhibitory effect on tyrosinase].[Pubmed:25464797]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Aug;31(4):833-6, 841.
The present paper intends to discuss the antioxidant and tyrosinase inhibition effect of Solanesol from three aspects of ultraviolet radiation and free radical scavenging. The paper makes a survey on diurnal variation rule of the minimum ultraviolet transmittance and ultraviolet transmittance of Solanesol, hydroxyl (OH) free radical scavenging method of Smirnoff reaction system model, superoxide anion O2- free radical scavenging method of pyrogallol autoxidation, and the inhibitory effect of Solanesol on tyrosinase activity by enzyme kinetic method. The experiment results showed that Solanesol could effectively scavenge lipid radicals to block lipid peroxidation, and inhibit effects on tyrosinase. Solanesol is a natural extract which could be used to prevent senile atrophy of human skin and senile plaque.
Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70.[Pubmed:25645596]
Toxicol In Vitro. 2015 Apr;29(3):600-8.
In present study, we showed that the mRNA and protein levels of HO-1 and Hsp70 in Solanesol-treated L02 cells were significantly increased. The induction of the HO-1 by Solanesol is majorly achieved via enhancing the nuclear translocation and transactivity of Nrf2 through enhancement of Hsp90-Keap1 interaction, while Solanesol-elevated Hsp70 is related with promoting the nuclear translocation of HSF1 through the involvement of chaperones interaction. Furthermore, the induction of HO-1 and Hsp70 by Solanesol could protect against ethanol-induced liver injury, including significantly suppressing the elevation of the activities of LDH and AST, attenuating ethanol-induced increase of the MDA, ROS level and decrease of the GSH level. Moreover, Solanesol also suppressed ethanol-induced apoptosis of L02 cells by inhibition of nuclear morphological damage, procaspase 3 and cleavage of caspase 3 and PARP, suggesting Solanesol may be beneficial against ALD. Solanesol also promoted tBHQ-mediated protective effects. However, treatment cells with SnPP or PES markedly abrogated the protective effects of Solanesol on ethanol-induced cell injury. These results strongly suggested that Solanesol could protect ethanol-induced L02 cell damage, which might be attributed to the activation of HO-1 and Hsp70.
