Home >> Research Area >>Metabolism>>FAAH>> TAK 21d

TAK 21d

Potent FAAH inhibitor CAS# 1143578-94-2

TAK 21d

Catalog No. BCC5609----Order now to get a substantial discount!

Product Name & Size Price Stock
TAK 21d: 5mg $115 In Stock
TAK 21d: 10mg Please Inquire In Stock
TAK 21d: 20mg Please Inquire Please Inquire
TAK 21d: 50mg Please Inquire Please Inquire
TAK 21d: 100mg Please Inquire Please Inquire
TAK 21d: 200mg Please Inquire Please Inquire
TAK 21d: 500mg Please Inquire Please Inquire
TAK 21d: 1000mg Please Inquire Please Inquire
Related Products
  • Skepinone-L

    Catalog No.:BCC1953
    CAS No.:1221485-83-1
  • SB202190 (FHPI)

    Catalog No.:BCC1093
    CAS No.:152121-30-7
  • SB 239063

    Catalog No.:BCC1923
    CAS No.:193551-21-2
  • SD-06

    Catalog No.:BCC1937
    CAS No.:271576-80-8
  • LY2228820

    Catalog No.:BCC2528
    CAS No.:862507-23-1

Quality Control of TAK 21d

Number of papers citing our products

Chemical structure

TAK 21d

3D structure

Chemical Properties of TAK 21d

Cas No. 1143578-94-2 SDF Download SDF
PubChem ID 57749996 Appearance Powder
Formula C19H17F2N7O M.Wt 397.38
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 10 mM in DMSO and to 20 mM in 1eq. HCl
Chemical Name 4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-pyridazin-3-ylpiperazine-1-carboxamide
SMILES C1CN(CCN1C2=NC=CC(=N2)C3=CC(=C(C=C3)F)F)C(=O)NC4=NN=CC=C4
Standard InChIKey JCWVFSJNIBAGQN-UHFFFAOYSA-N
Standard InChI InChI=1S/C19H17F2N7O/c20-14-4-3-13(12-15(14)21)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of TAK 21d

DescriptionPotent FAAH inhibitor; (IC50 values are 0.28 and 0.72 nM, at rat and human FAAH respectively). Displays analgesic effects in vivo models of neuropathic and inflammatory pain. Brain penetrant.

TAK 21d Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

TAK 21d Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of TAK 21d

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5165 mL 12.5824 mL 25.1648 mL 50.3297 mL 62.9121 mL
5 mM 0.5033 mL 2.5165 mL 5.033 mL 10.0659 mL 12.5824 mL
10 mM 0.2516 mL 1.2582 mL 2.5165 mL 5.033 mL 6.2912 mL
50 mM 0.0503 mL 0.2516 mL 0.5033 mL 1.0066 mL 1.2582 mL
100 mM 0.0252 mL 0.1258 mL 0.2516 mL 0.5033 mL 0.6291 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on TAK 21d

Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.[Pubmed:24440478]

Bioorg Med Chem. 2014 Feb 15;22(4):1468-78.

A series of piperazine ureas were designed, synthesized, and evaluated for their potential as novel orally efficacious fatty acid amide hydrolase (FAAH) inhibitors for the treatment of neuropathic and inflammatory pain. We carried out an optimization study of compound 5 to improve its in vitro FAAH inhibitory activity, and identified the 2-pyrimidinylpiperazine derivative 21d with potent inhibitory activity, favorable DMPK profile and brain permeability. Compound 21d showed robust and dose-dependent analgesic efficacy in animal models of both neuropathic and inflammatory pain.

Keywords:

TAK 21d,1143578-94-2,Natural Products,FAAH, buy TAK 21d , TAK 21d supplier , purchase TAK 21d , TAK 21d cost , TAK 21d manufacturer , order TAK 21d , high purity TAK 21d

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: