ZAPA sulfateAgonist at 'low affinity' GABAA receptor. More potent than GABA/muscimol CAS# 371962-01-5 |
- Ebrotidine
Catalog No.:BCC1542
CAS No.:100981-43-9
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 371962-01-5 | SDF | Download SDF |
| PubChem ID | 90479730 | Appearance | Powder |
| Formula | C4H8N2O6S2 | M.Wt | 244.24 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 10 mM in water | ||
| Chemical Name | (Z)-3-carbamimidoylsulfanylprop-2-enoic acid;sulfuric acid | ||
| SMILES | C(=CSC(=N)N)C(=O)O.OS(=O)(=O)O | ||
| Standard InChIKey | UWVNHPNVOMFDHW-ODZAUARKSA-N | ||
| Standard InChI | InChI=1S/C4H6N2O2S.H2O4S/c5-4(6)9-2-1-3(7)8;1-5(2,3)4/h1-2H,(H3,5,6)(H,7,8);(H2,1,2,3,4)/b2-1-; | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | More potent than either GABA or muscimol as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. Also a GABAA-ρ receptor antagonist. |
ZAPA sulfate Dilution Calculator
ZAPA sulfate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.0943 mL | 20.4717 mL | 40.9433 mL | 81.8867 mL | 102.3583 mL |
| 5 mM | 0.8189 mL | 4.0943 mL | 8.1887 mL | 16.3773 mL | 20.4717 mL |
| 10 mM | 0.4094 mL | 2.0472 mL | 4.0943 mL | 8.1887 mL | 10.2358 mL |
| 50 mM | 0.0819 mL | 0.4094 mL | 0.8189 mL | 1.6377 mL | 2.0472 mL |
| 100 mM | 0.0409 mL | 0.2047 mL | 0.4094 mL | 0.8189 mL | 1.0236 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- YM201636
Catalog No.:BCC4996
CAS No.:371942-69-7
- PI-103 Hydrochloride
Catalog No.:BCC1860
CAS No.:371935-79-4
- PI-103
Catalog No.:BCC1162
CAS No.:371935-74-9
- Flavoxate hydrochloride
Catalog No.:BCC5208
CAS No.:3717-88-2
- 4'-Amino-3',5'-dichloroacetophenone
Catalog No.:BCC8678
CAS No.:37148-48-4
- Murrangatin
Catalog No.:BCN5426
CAS No.:37126-91-3
- IC-87114
Catalog No.:BCC1161
CAS No.:371242-69-2
- Azlocillin sodium salt
Catalog No.:BCC4763
CAS No.:37091-65-9
- Procyanidin C1
Catalog No.:BCN6317
CAS No.:37064-30-5
- Z-Glu-OBzl
Catalog No.:BCC2780
CAS No.:3705-42-8
- Cyclo(Gly-L-Pro)
Catalog No.:BCN4059
CAS No.:3705-27-9
- Cyclo(L-Phe-L-Pro)
Catalog No.:BCN4029
CAS No.:3705-26-8
- SB 612111 hydrochloride
Catalog No.:BCC7714
CAS No.:371980-94-8
- L-Citruline
Catalog No.:BCN2692
CAS No.:372-75-8
- Capsidiol
Catalog No.:BCC8140
CAS No.:37208-05-2
- Citromycin
Catalog No.:BCN7459
CAS No.:37209-30-6
- PIK-75
Catalog No.:BCC1163
CAS No.:372196-77-5
- Sieber Linker
Catalog No.:BCC2835
CAS No.:3722-51-8
- Wilforgine
Catalog No.:BCN5427
CAS No.:37239-47-7
- Wilfortrine
Catalog No.:BCN3085
CAS No.:37239-48-8
- Wilfordine
Catalog No.:BCN3083
CAS No.:37239-51-3
- TCS OX2 29
Catalog No.:BCC7670
CAS No.:372523-75-6
- Sennoside C
Catalog No.:BCN1004
CAS No.:37271-16-2
- Sennoside D
Catalog No.:BCN1005
CAS No.:37271-17-3
GABAc receptors: relatively simple transmitter -gated ion channels?[Pubmed:8885697]
Trends Pharmacol Sci. 1996 Sep;17(9):319-23.
The inhibitory neurotransmitter, GABA, activates a variety of receptors in all areas of the CNS. Two major subtypes of GABA receptors are well known: (1) GABAA receptors are ligand-gated Cl- channels that consist of a heteromeric mixture of protein subunits forming a pentameric structure, and (2) GABAB receptors couple to Ca2+ and K+ channels via G proteins and second messengers. Here, Graham Johnston discusses evidence for a third major subclass of GABA receptors. GABAC receptors appear to be relatively simple ligand-gated Cl- channels with a distinctive pharmacology, in that they are not blocked by bicuculline and not modulated by barbiturates, benzodiazepines or neuroactive steroids. Compared with GABAA receptors, GABAC receptors are activated at lower concentrations of GABA and are less liable to desensitization. In addition, their channels open for a longer time. The pharmacology of these novel subtypes of GABA receptors may yield important therapeutic agents.
ZAPA, (Z)-3-[(aminoiminomethyl)thio]-2-propenoic acid hydrochloride, a potent agonist at GABA-receptors on the Ascaris muscle cell.[Pubmed:2851353]
Br J Pharmacol. 1988 Sep;95(1):3-5.
This study is the first report of a compound which is equal in efficacy to gamma-aminobutyric acid (GABA) at the nematode Ascaris muscle GABA-receptor. The GABA-receptor at the Ascaris muscle cell which mediates a membrane hyperpolarization and muscle relaxation has eluded classification. The structure-activity profile of this receptor is not typical of GABAA or GABAB-receptors. Here we report that the isothiouronium compound ZAPA is as potent as GABA at this receptor. This finding has important implications for the characterization of the Ascaris GABA-receptor and the design of novel anthelmintics.
Isothiouronium compounds as gamma-aminobutyric acid agonists.[Pubmed:3015310]
Br J Pharmacol. 1986 Jun;88(2):379-87.
Analogues of gamma-aminobutyric acid (GABA) incorporating an isothiouronium salt as a replacement for a protonated amino functional group have been investigated for activity on: GABA receptors in the guinea-pig ileum; [3H]-GABA and [3H]-diazepam binding to rat brain membranes; and GABA uptake and transamination. For the homologous series of omega-isothiouronium alkanoic acids, maximum GABA-mimetic activity was found at 3-[(aminoiminomethyl)thio]propanoic acid. Introduction of unsaturation into this compound gave two isomeric conformationally restricted analogues. The trans isomer was inactive at GABA receptors while the cis compound ((Z)-3-[(aminoiminomethyl)thio]prop-2-enoic acid (ZAPA)) was more potent than muscimol and GABA as a GABA agonist with respect to low affinity GABA receptor sites. Both isomers were moderately potent at inhibiting the uptake of [3H]-GABA into rat brain slices. Comparison of possible conformations of the two unsaturated isomers by interactive computer graphics modelling and comparison with muscimol has led to a plausible active conformation of ZAPA, which may be a selective and potent agonist for low affinity GABA binding sites.
