Ischemia-Reperfusion Injury Research

Ischemia/Reperfusion (I/R) injury is defined as the cellular damage that results from a period of ischemia that is followed by the reestablishment of the blood supply to the infarcted tissue.Myocardial ischemia, also known as cardiac ischemia, is defined as the deprivation of oxygen and nutrients to the heart. This phenomenon occurs during a myocardial infarction, when an occlusive thrombus within a coronary artery prevents blood supply to the myocardium, but can also occur during cardiac surgery as a result of pharmacological intervention to temporarily stop the heart. Reperfusion restores blood supply to ischemic tissue, but this is paradoxically associated with further tissue damage.

Ischemia-Reperfusion Injury Research Products Targets

Products for Ischemia-Reperfusion Injury Research - Page 11

Cat.No. Product Name Information/Activity
BCC2394 Bax inhibitor peptide V5 Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
BCC2395 Bax inhibitor peptide, negative control Negative control peptide for Bax inhibitor peptide V5
BCC3593 HA14-1 HA14-1 is a Bcl-2/Bcl-XL antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC50 of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function.
BCC4098 Marinopyrrole A Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM).
BCC2256 Methylprednisolone Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties.
BCN2702 Gossypol Gossypol, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
BCC2397 Muristerone A Stimulates Bcl-XL mRNA transcription; antiapoptotic
BCC2398 SU 9516 SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also shows inhibitory effects on CDK1 and CDK4, with IC50s of 40, 200 nM, respectively.
BCC2350 Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor
BCC2351 Calpeptin Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets. Calpeptin is also an inhibitor of cathepsin K.