Huntington's Disease Research

Huntington's disease is a neurodegenerative disease characterized by cognitive decline and motor dysfunction. It is a genetic disorder which results in the production of mutant huntingtin protein (mHtt). This protein aggregates in the cell cytoplasm and nucleus, affecting cellular function.

Huntington's Disease Research Products Targets

Products for Huntington's Disease Research - Page 4

Cat.No. Product Name Information/Activity
BCC3914 Bafilomycin A1 Bafilomycin A1, a macrolide antibiotic isolated from the Streptomyces species, is a specific inhibitor of vacuolar-type H+ ATPase (V-ATPase). Bafilomycin A1 inhibits autophagy and induces apoptosis.
BCC3918 (±)-Bay K 8644 Ca<sup>2+</sup> channel activator (L-type); aids generation of iPSCs from MEFs
BCC3919 Concanamycin A Concanamycin A (Antibiotic X 4357B) is a macrolide antibiotic and a specific vacuolar type H+-ATPase (V-ATPase) inhibitor.
BCC3916 DBeQ DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM.
BCC1127 E 64d Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor.
BCC4500 GW4064 GW 4064 is a potent FXR agonist with an EC50 of 65 nM.
BCC5560 Hydroxychloroquine Sulfate Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling.
BCC3714 3-Methyladenine 3-Methyladenine is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.
BCC5604 ML 240 ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.
BCC3826 Nocodazole Nocodazole is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, and activates CRISPR/Cas9.