Schizophrenia Research

Schizophrenia is a chronic, debilitating mental disorder affecting 1-2% of the global population. Symptoms are split into two types; 'positive' symptoms, including delusions and hallucinations, and 'negative' symptoms, including anhedonia and lack of motivation. Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Several neurobiological alterations in brain structure, physiology and neurochemistry have been documented, along with an ever-increasing list of susceptibility genes.

Schizophrenia Research Products Targets

Products for Schizophrenia Research - Page 13

  1. Cat.No. Product Name Information/Activity
  2. BCC2464 Okadaic acid Okadaic acid is extracted from black sponges of the genus Halichondria. Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A and PP3 inhibitor with IC50s of 10-15 nM, 0.5 nM and 4 nM, respectively. Okadaic acid eliminate metazoan symbionts/parasites by apoptosis. Okadaic acid chemical structure
  3. BCC2465 Sal 003 Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. Sal 003 chemical structure
  4. BCC4843 Salubrinal Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay. Salubrinal chemical structure
  5. BCC6481 Sanguinarine chloride Sanguinarine chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB. Sanguinarine chloride chemical structure
  6. BCC7320 Tautomycetin 119757-73-2 Tautomycetin chemical structure
  7. BCC2458 Ceramide Ser/Thr protein phosphatase activator Ceramide chemical structure
  8. BCN2195 Dopamine hydrochloride Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist. Dopamine hydrochloride chemical structure
  9. BCC4814 (+,-)-Octopamine HCl Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) is an endogenous biogenic amine that is closely related to norepinephrine, and has effects on the adrenergic and dopaminergic systems. (+,-)-Octopamine HCl chemical structure
  10. BCC7928 BIMU 8 Potent 5-HT<sub>4</sub> receptor full agonist BIMU 8 chemical structure
  11. BCC4207 Cisapride 81098-60-4 Cisapride chemical structure

Items 121 to 130 of 709 total