Schizophrenia Research

Schizophrenia is a chronic, debilitating mental disorder affecting 1-2% of the global population. Symptoms are split into two types; 'positive' symptoms, including delusions and hallucinations, and 'negative' symptoms, including anhedonia and lack of motivation. Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Several neurobiological alterations in brain structure, physiology and neurochemistry have been documented, along with an ever-increasing list of susceptibility genes.

Schizophrenia Research Products Targets

Products for Schizophrenia Research - Page 12

  1. Cat.No. Product Name Information/Activity
  2. BCC2459 DL-AP3 Phosphoserine phosphatase inhibitor DL-AP3 chemical structure
  3. BCC2456 Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor Calcineurin Autoinhibitory Peptide chemical structure
  4. BCC2457 Calyculin A Calyculin A is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM. Calyculin A chemical structure
  5. BCN1280 Cantharidin Cantharidin, a natural toxin isolated from beetles in the families Meloidae and Oedemeridae, has been reported to be toxic to some pests, including the diamondback moth. Cantharidin chemical structure
  6. BCC4773 Cyclosporin A Cyclosporin A is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion. Cyclosporin A chemical structure
  7. BCC4952 Tacrolimus (FK506) Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. Tacrolimus (FK506) chemical structure
  8. BCC2460 Fostriecin sodium salt Potent PP2A and PP4 inhibitor Fostriecin sodium salt chemical structure
  9. BCC2461 Fumonisin B1 Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin. Fumonisin B1 chemical structure
  10. BCC4179 GSK 2830371 GSK 2830371 is a highly selective Wip1 phosphatase inhibitor with IC50 of 6 nM. GSK 2830371 chemical structure
  11. BCC2462 INCA-6 Inhibitor of calcineurin-substrate association INCA-6 chemical structure

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