Schizophrenia Research

Schizophrenia is a chronic, debilitating mental disorder affecting 1-2% of the global population. Symptoms are split into two types; 'positive' symptoms, including delusions and hallucinations, and 'negative' symptoms, including anhedonia and lack of motivation. Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Several neurobiological alterations in brain structure, physiology and neurochemistry have been documented, along with an ever-increasing list of susceptibility genes.

Schizophrenia Research Products Targets

Products for Schizophrenia Research - Page 9

  1. Cat.No. Product Name Information/Activity
  2. BCC7814 CDP 840 hydrochloride Potent and selective PDE4 inhibitor CDP 840 hydrochloride chemical structure
  3. BCC7338 CGH 2466 dihydrochloride Anti-inflammatory agent. Inhibitor of PDE4 and p38 MAPK, also adenosine receptor antagonist CGH 2466 dihydrochloride chemical structure
  4. BCC6843 Cilostamide Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity. Cilostamide chemical structure
  5. BCC2291 Cilostazol Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM. Cilostazol chemical structure
  6. BCC7155 Enoximone 77671-31-9 Enoximone chemical structure
  7. BCC6648 Etazolate hydrochloride 35838-58-5 Etazolate hydrochloride chemical structure
  8. BCC7502 IBMX IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively. IBMX chemical structure
  9. BCC7188 ICI 63197 27277-00-5 ICI 63197 chemical structure
  10. BCC7066 MDL 12330A hydrochloride Cyclic nucleotide PDE inhibitor; also adenylyl cyclase inhibitor MDL 12330A hydrochloride chemical structure
  11. BCC7549 Mesopram 189940-24-7 Mesopram chemical structure

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