Schizophrenia Research

Schizophrenia is a chronic, debilitating mental disorder affecting 1-2% of the global population. Symptoms are split into two types; 'positive' symptoms, including delusions and hallucinations, and 'negative' symptoms, including anhedonia and lack of motivation. Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Several neurobiological alterations in brain structure, physiology and neurochemistry have been documented, along with an ever-increasing list of susceptibility genes.

Schizophrenia Research Products Targets

Products for Schizophrenia Research - Page 3

  1. Cat.No. Product Name Information/Activity
  2. BCC6768 Imetit dihydrobromide Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM). Imetit dihydrobromide chemical structure
  3. BCC6853 Immepip dihydrobromide 164391-47-3 Immepip dihydrobromide chemical structure
  4. BCC7524 Methimepip dihydrobromide 817636-54-7 Methimepip dihydrobromide chemical structure
  5. BCC5665 (R)-(-)-α-Methylhistamine dihydrobromide (R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a Kd of 50.3 nM. (R)-(-)-α-Methylhistamine dihydrobromide can cross the blood-brain barrier, and can enhance memory retention, attenuates memory impairment in rats. (R)-(-)-α-Methylhistamine dihydrobromide chemical structure
  6. BCC6700 (S)-(+)-α-Methylhistamine dihydrobromide 75614-93-6 (S)-(+)-α-Methylhistamine dihydrobromide chemical structure
  7. BCC6701 Nα-Methylhistamine dihydrochloride 16503-22-3 Nα-Methylhistamine dihydrochloride chemical structure
  8. BCC7378 Proxyfan oxalate 177708-09-7 Proxyfan oxalate chemical structure
  9. BCC7963 A 331440 dihydrochloride Selective H<sub>3</sub> antagonist A 331440 dihydrochloride chemical structure
  10. BCC1863 Pitolisant hydrochloride Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM). Pitolisant hydrochloride chemical structure
  11. BCC7291 Carcinine ditrifluoroacetate 56897-53-1 Carcinine ditrifluoroacetate chemical structure

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