Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 81 - 88 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1173 | Cladribine |
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Adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC<sub>50</sub> = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC<sub>50</sub> = 0.11 - 0.28 <span class='symbol'>μ</span>M). Displays activity <em>in vitro</em> and <em>in vivo</em>. Orally bioavailable.
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| BCC1175 | 17-DMAG (Alvespimycin) HCl |
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Water-soluble analog of 17-AAG and geldanamycin. Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI<sub>50</sub> values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).
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| BCC1176 | Stattic |
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Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.
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| BCC1177 | BMS-536924 |
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Dual inhibitor of the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) (IC50 values are 73 and 100 nM respectively). Inhibits receptor autophosphorylation and downstream MEK1/2 and Akt signaling. Induces G1 arrest and apoptosis in ML-1 cells; also inhibits cell proliferation in multiple tumor types. Reverses EMT through the attenuation of Snail mRNA expression in MCF10A cell over expressing IGF1R.
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| BCC1178 | T0901317 |
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Potent, high affinity liver X receptor (LXR) agonist (EC<sub>50</sub> ~ 50 nM, K<sub>d</sub> values are 7 and 22 nM for LXR-<span class='symbol'>α</span> and LXR-<span class='symbol'>β</span> respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-<span class='symbol'>β</span> production in primary neurons <em>in vitro</em>. Displays an EC<sub>50</sub> of ~ 5 <span class='symbol'>μ</span>M for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).
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| BCC1181 | PHA-665752 |
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Potent, selective and ATP-competitive inhibitor of MET kinase (IC<sub>50</sub> values are 9, 68, 200, 1400, 3000, 3800 and 6000 nM for MET, Ron, Flk-1, c-abl, FGFR1, EGFR and c-src respectively and > 10000 nM for IGF-IR, PDGFR, AURORA2, PKA, PKB<span class='symbol'>α</span>, p38<span class='symbol'>α</span>, MK2 and MK3). Antitumor agent; inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.
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| BCC1183 | TCS 359 |
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Potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).
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| BCC1184 | Dexamethasone (DHAP) |
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Glucocorticoid; anti-inflammatory. Reduces levels of activated NF-<span class='symbol'>κ</span>B in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also induces autophagy in acute lymphoblastic leukemia (ALL) cell lines.
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