Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 73 - 80 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1150 | Etomidate |
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General anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with <span class='symbol'>β</span>2- and <span class='symbol'>β</span>3-subunit containing GABA<sub>A</sub> receptors. Short acting and potent hypnotic, with low toxicity.
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| BCC1151 | Etoposide |
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Etoposide is a chemotherapy medication used for the treatments of a number of types of cancer. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA, it induces apoptosis in MCF-7 breast cancer cells.
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| BCC1152 | SNS-032 (BMS-387032) |
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Potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). Displays no activity against 190 additional kinases (IC50 >1000 nM). Arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.
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| BCC1153 | Bendamustine HCl |
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Cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.
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| BCC1155 | Ki16425 |
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Antagonist of the lysophosphatidic acid receptors LPA<sub>1</sub> and LPA<sub>3</sub> (K<sub>i</sub> values are 0.25 and 0.36 <span class='symbol'>μ</span>M respectively, in a GTP<span class='symbol'>γ</span>S binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.
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| BCC1159 | PQ 401 |
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Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC<sub>50</sub> value of 12 <span class='symbol'>μ</span>M. Inhibits growth of MCF-7 breast cancer cells <em>in vitro</em> and <em>in vivo</em>.
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| BCC1167 | Bosutinib (SKI-606) |
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Dual inhibitor of Abl and Src kinases (IC50 = 1.2 nM for Src in an enzymatic assay). Displays antiproliferative activity against chronic myelogenous leukemia (CML) cells and decreases the motility and invasion of breast cancer cell lines. Also exhibits potent antiproliferative activity in anchorage-independent, Src-transformed rat fibroblasts (IC50 = 100 nM). Displays selectivity for Src over non-Src family kinases such as growth factor receptor tyrosine kinases.
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| BCC1170 | Carboplatin |
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Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin.
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