Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 41 - 48 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1088 | Dynasore |
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Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.
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| BCC1089 | Prasugrel |
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Irreversible P2Y12 antagonist; metabolised to active metabolite R-99224 (IC50 = 45 μM) irreversibly binds platelet P2Y12 receptors, inhibiting platelet activation. Antiplatelet and antithrombotic. Orally active and active in vivo. Note - inactive in vitro.
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| BCC1090 | GANT61 |
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GLI antagonist that inhibits GLI1 and GLI2-induced transcription (IC<sub>50</sub> ~ 5 <span class='symbol'>μ</span>M). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity <em>in vivo</em>. Inhibits the pluripotency factors Oct4, Sox-2, Nanog and c-Myc in pancreatic cancer stem cells.
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| BCC1092 | Epothilone B (EPO906, Patupilone) |
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Microtubule stabilization agent that promotes tubulin polymerization and induces G<sub>2</sub>-M cell cycle arrest (EC<sub>50</sub> = 32 nM in HeLa cells). Inhibits proliferation of human carcinoma cell lines <em>in vitro</em>, including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent cytotoxicity in MCF-7 and A549 cells (EC<sub>50</sub> values are 0.3 and 2.7 nM respectively). Inhibits growth of HCT-15 tumors in mice <em>in vivo</em>.
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| BCC1093 | SB202190 (FHPI) |
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A highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (K<sub>d</sub> = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38<span class='symbol'>α</span> and <span class='symbol'>β</span> isoforms (IC<sub>50</sub> = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38<span class='symbol'>β</span>2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Also available as part of the MAPK Inhibitor.
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| BCC1096 | GW2580 |
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Potent and selective cFMS kinase inhibitor (IC<sub>50 </sub> = 0.06 <span class='symbol'>μ</span>M). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes <em>in vitro</em>. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.
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| BCC1098 | PD98059 |
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Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC<sub>50</sub> = 2-7 <span class='symbol'>μ</span>M). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G<sub>1</sub> arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the MAPK Cascade Inhibitor and MAPK Inhibitor.
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| BCC1099 | Celecoxib |
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Selective cyclooxygenase-2 (COX-2) inhibitor (IC<sub>50</sub> values are 15 and 0.04 <span class='symbol'>μ</span>M for COX-1 and COX-2 respectively). Anti-inflammatory with shorter plasma half-life <em>in vivo</em> than SC 58121. Displays chemopreventive activity in <em>in vivo</em> tumor models.
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