Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 89 - 96 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1185 | Cyclophosphamide |
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Nitrogen mustard alkylating agent and prodrug. Phosphoramide mustard (active metabolite) forms DNA cross-links leading to cell death. Inhibits aldehyde dehydrogenase 1 (ALDH1) through its degradation product acrolein. Chemotherapeutic for the treatment of breast cancer; regulates Bax and Bcl-2 expression when administered with etoposide in breast cancer cell lines.
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| BCC1186 | Mercaptopurine (6-MP) |
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Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis.
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| BCC1187 | Floxuridine |
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Antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.
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| BCC1189 | Acitretin |
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1. Acitretin for chemoprevention of non-melanoma skin cancers in renal transplant recipients.
2. Acitretin dramatically improves the results of UV-B treatment in patients with severe psoriasis and it markedly decreases the effective cumulative UV-B dose. 3. Acitretin in the treatment of severe lichen sclerosus et atrophicus of the vulva. 4. Acitretin therapy is effective for psoriasis associated with human immunodeficiency virus infection. 5. Acitretin has immunomodulatory effect, and low dose acitretin therapy is safe, well tolerated and partially effective in chemoprophylaxis of skin cancer in renal transplant recipients. |
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| BCC1190 | Acarbose |
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Inhibitor of intestinal <span class='symbol'>α</span>-glucosidase (IC<sub>50</sub> = 11 nM). Antidiabetic; inhibits the hydrolysis of complex carbohydrates.
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| BCC1191 | Fluoxetine HCl |
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Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a K<sub>i</sub> of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT<sub>1A</sub>, 5-HT<sub>2A</sub>, H<sub>1</sub>, <span class='symbol'>α</span><sub>1</sub>, <span class='symbol'>α</span><sub>2</sub>-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics.
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| BCC1192 | Epirubicin HCl |
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Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC<sub>50</sub> = 62.7 <span class='symbol'>μ</span>M in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.
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| BCC1199 | Ampicillin |
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Antibiotic. Widely used selection reagent for transformed cells expressing <span class='symbol'>β</span>-lactamase.
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