Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 137 - 144 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1305 | 25-Hydroxy VD2-D6 |
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25-Hydroxy VD2-D6 is a labelled metabolite of Vitamin D2.
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| BCC1306 | 3,3'-Diindolylmethane |
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Activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
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| BCC1312 | 5-Iodotubercidin |
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Potent adenosine kinase inhibitor (IC<sub>50</sub> = 26 nM). Also nucleoside transporter inhibitor (IC<sub>50</sub> values are < 25 nM, 7 <span class='symbol'>μ</span>M and 15 <span class='symbol'>μ</span>M for inhibition of [<sup>3</sup>H]adenosine, [<sup>3</sup>H]uridine and [<sup>3</sup>H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC<sub>50</sub> values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 <span class='symbol'>μ</span>M respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition <em>in vivo</em>.
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| BCC1314 | 7-Epi 10-Desacetyl Paclitaxel |
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7-Epi-10-deacetyltaxol shows IC50 values of 0.085 nM, against HeLa cells.
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| BCC1315 | 9-Dihydro-13-acetylbaccatin III |
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9-Dihydro-13-acetylbaccatin III shows cytotoxicity against the MCF7 cell line and drug resistant cell line MCF7-ADR.
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| BCC1317 | A 438079 hydrochloride |
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Competitive P2X<sub>7</sub> receptor antagonist (pIC<sub>50</sub> = 6.9 for the inhibition of Ca<sup>2+</sup> influx in the human recombinant P2X<sub>7</sub> cell line). Devoid of activity at other P2 receptors (IC<sub>50</sub> >> 10 <span class='symbol'>μ</span>M). Possesses antinociceptive activity in models of neuropathic pain <em>in vivo</em>.
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| BCC1319 | A 83-01 |
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Potent inhibitor of TGF-<span class='symbol'>β</span> type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC<sub>50</sub> values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-<span class='symbol'>β</span>-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than ItemId=54518'>SB 431542</a> (Cat.No. 1614). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term <em>in vitro</em> self-renewal of human iPSCs.
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| BCC1322 | A-740003 |
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Potent and selective P2X<sub>7</sub> receptor antagonist (IC<sub>50</sub> values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 <span class='symbol'>μ</span>M. Reduces nociception in animal models of persistent neuropathic and inflammatory pain. Also reduces neuroblastoma tumor growth in mice.
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