Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN8168 | Neoruscogenin |
| 1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors. | |
| BCN8155 | Acetagastrodin |
| 1. Acetagastrodin treatment may be an effective treatment to protect retinal neurons against such functional impairment during the early stages of diabetes. 2. Acetagastrodin has antispasmodic effect on vascular smooth muscle. | |
| BCN8191 | Lupinalbin A |
| 1. Lupinalbin A exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathway activation. 2. Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). | |
| BCN8147 | Pterosin A |
| 1. Pterosin A is a novel activator of adenosine monophosphate-activated protein kinase, which is crucial for regulating blood glucose homeostasis, 2. Pterosin A has potential anti-diabetic activity, it can significantly reverse the increased serum insulin and insulin resistance (IR) in dexamethasone-IR mice and in db/db mice. | |
| BCN8179 | Sulforaphene |
| 1. Sulforaphene has herbicidal activity, the ED50 of it against velvetleaf seedlings was approximately 2×10(-4) M. 2. Sulforaphene may be a potential anti- triple negative breast cancer natural compound and its antiproliferation effects may be mediated by tumor suppressor Egr1. 3. Sulforaphene has chemotherapeutic potential, it promotes Bax/Bcl2, MAPK-dependent human gastric cancer AGS cells apoptosis and inhibits migration via EGFR, p-ERK1/2 down-regulation. 4. Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway. 5. Sulforaphene has anti-proliferative and antibacterial properties. | |
| BCN8176 | Nornicotine |
| 1. Nornicotine serves as the direct precursor in the synthesis of N'-nitrosonornicotine, a potent carcinogen in laboratory animals. 2. Nornicotine and nicotine each produced a dose-dependent decrease in nicotine self-administration, nornicotine may be an effective treatment for tobacco dependence. 3. Nornicotine inhibits striatal dopamine transporter (DAT) function via a nicotinic receptor (nAChR) -mediated mechanism. 4. S(-)-Nornicotine may be of value, either alone or in combination with an opioid, for treatment of a broad-spectrum of pain (i.e. nociceptive, neuropathic, and mixed pain). 5. Nornicotine and nicotine can promote endothelial cellular proliferation, migration and tube formation of HUVECs in vitro. | |
| BCN8159 | Ptaquiloside |
| 1. Ptaquiloside is a natural toxin produced by bracken (Pteridium aquilinum [L.] Kuhn), it shows genotoxicity. 2. Ptaquiloside has immunosuppressive effects, it reduces NK cell activities by enhancing metallothionein expression, which is prevented by selenium. 3. Ptaquiloside has carcinogenic effects. | |
| BCN8175 | 5'-IMPdisodium salt |
| 1. Used in enzyme analysis; flavour enhancer. | |
