Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 177 - 184 of 9359 hot products
| Catalog No. | Product Name |
|---|---|
| BCC1507 | CZC24832 |
|
Selective inhibitor of PI 3-kinase <span class='symbol'>γ</span> (IC<sub>50</sub> = 1.0 <span class='symbol'>μ</span>M in a PI 3-K<span class='symbol'>γ</span>-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease.
|
|
| BCC1508 | D4476 |
|
Selective inhibitor of casein kinase 1 (CK1) and TGF-<span class='symbol'>β</span> type-I receptor (ALK5) that displays > 20-fold selectivity over SAPK2/p38 and a much greater selectivity over all other protein kinases tested. Suppresses site-specific phosphorylation and nuclear exclusion of FOXO1a.
|
|
| BCC1509 | D609 |
|
Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K<sub>i</sub> = 6.4 <span class='symbol'>μ</span>M); antiviral and antitumor agent. Suppresses LPS- and IFN<span class='symbol'>γ</span>-induced NO production (IC<sub>50</sub> = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant <em>in vivo</em>.
|
|
| BCC1510 | D-64131 |
|
Novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.
|
|
| BCC1514 | Daminozide |
|
Histone demethylase KDM2/7 subfamily inhibitor (IC<sub>50</sub> values are 0.55, 1.5 and 2.1 <span class='symbol'>μ</span>M for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC<sub>50</sub> > 100 <span class='symbol'>μ</span>M).
|
|
| BCC1525 | Desmopressin |
|
Synthetic vasopressin analog that acts as an agonist at V<sub>1B</sub> and V<sub>2</sub> receptors (EC<sub>50</sub> values are 11.4 and 23.9 nM and K<sub>i</sub> values are 5.84 and 65.9 nM respectively). Prevents polycystic kidney disease formation and exhibits antidiuretic, antiproliferative, hemostatic and hypotensive activity <em>in vivo</em>.
|
|
| BCC1539 | DY131 |
|
Novel selective agonist at estrogen-related receptors ERR<span class='symbol'>β</span> and ERR<span class='symbol'>γ</span>. Displays minimal activity at ERR<span class='symbol'>α</span>, ER<span class='symbol'>α</span> and ER<span class='symbol'>β</span> at concentrations up to 30 <span class='symbol'>μ</span>M.
|
|
| BCC1547 | Elacridar hydrochloride |
|
P-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin and vincristine in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active.
|
|