Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 233 - 240 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1780 | MTEP hydrochloride |
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Potent, selective and non-competitive mGlu5 antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki= 16 nM). Displays anxiolytic activity in vivo and is orally active.
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| BCC1790 | NBD-556 |
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CD4 mimetic (IC50 values are in low micromolar range, dependent on cell type and HIV strain). Recognizes and induces structural changes in HIV-1 envelope protein gp120, analogous to CD4 binding. Inhibits HIV-1 cell entry in CXCR4 and CCR5 expressing cell lines, by blocking virus-cell and cell-cell fusion.
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| BCC1794 | Nelfinavir Mesylate |
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Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (K<sub>i</sub> = 2 nM) <em>in vitro</em>.
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| BCC1799 | NG25 |
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TGF-<span class='symbol'>β</span>-activated kinase (TAK1) inhibitor (IC<sub>50</sub> = 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC<sub>50</sub> values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN-<span class='symbol'>α</span> and TLR7/8 agonist CL097-stimulated secretion of IFN-<span class='symbol'>β</span> in Gen 2.2 leukemia cells <em>in vitro</em>.
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| BCC1803 | NNC 55-0396 |
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Highly selective T-type calcium channel blocker. Displays IC<sub>50</sub> values of 6.8 and > 100 <span class='symbol'>μ</span>M for inhibition of Ca<sub>v</sub>3.1 T-type channels and HVA currents respectively in INS-1 cells.
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| BCC1808 | NPS-2143 hydrochloride |
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Selective Ca2+-sensing receptor antagonist. Blocks increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells (IC50 = 43 nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC50 = 41 nM). Orally active calcilytic compound.
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| BCC1809 | NS309 |
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Positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.
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| BCC1813 | NVP-BAG956 |
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Dual PDPK1 (PDK1) and class I PI 3-K inhibitor (IC<sub>50</sub> values are 245, 56, 446, 35 and 117 nM for PDPK1 and PI 3-K p110 -<span class ='symbol'>α</span>, -<span class ='symbol'>β</span>, -<span class ='symbol'>δ</span>, and -<span class ='symbol'>γ</span> respectively). Inhibits cellular AKT phosphorylation at Thr308. Blocks cell proliferation, causing arrest in G<sub>1</sub> phase of the cell cycle. Slows tumor progression in mouse xenograft models.
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