Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN7334 | Chalepensin |
| 1. Chalepensin shows antiprotozoal activity. 2. Chalepensin inhibits multiple P450s and that epoxidation activity is crucial for the potential drug interaction through mechanism-based inhibition. 3. Chalepensin can cause significant inhibition of radicle growth of A. hypochondriacus and E. crus-galli. 4. Chalepensin behaves as an energy transfer inhibitor at low concentration. | |
| BCN7339 | (+)-Aflavazole |
| 1. Aflavazole displays significant antifeedant activity against the fungivorous beetle Carpophilus hemipterus. | |
| BCC4450 | Adenine |
| Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry. Adenine, an AMP-activated protein kinase (AMPK) activator, can accelerate the diabetic wound healing by PPAR delta and angiogenic regulation; it also can increase the inhibitory activity of human interferon against encephalomyocarditis virus. Adenine can act as an efficient radiation-protecting agent at low concentration (2 micromol) and also inhibit cytostatic properties with regard to cancer cells at higher concentration. | |
| BCN7343 | N-Methyltaxol C |
| 1. N-methyltaxol C and paclitaxel can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolated heart. 2. N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. | |
| BCN7345 | Eupatolide |
| 1. Eupatolide sensitizes breast cancer cells to TRAIL through down-regulation of c-FLIP expression, it is a valuable compound to overcome TRAIL resistance in breast cancer cells. 2. Eupatolide can suppress PDGF-induced proliferation and migration of VSMC through HO-1 induction via ROS-Nrf2 pathway and may be a potential HO-1 inducer for preventing or treating vascular diseases. 3. Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation of TRAF6. 4. Eupatolide exhibits potent cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines, with IC50 values ranging from 1.57 to 22.58 uM. | |
| BCN7346 | Latisxanthone C |
| 1. Latisxanthone C shows inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, it may be a valuable antitumor promoter. | |
| BCN7347 | 1,5,6-Trihydroxy-3,7-dimethoxyxanthone |
| 1. 1,5,6-Trihydroxy-3,7-dimethoxyxanthone shows cytotoxic activity against the KB cell line. | |
| BCN6452 | Brevianamide F |
| 1. Brevianamide F shows antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). | |
