Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 241 - 248 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1819 | Olmesartan |
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Potent angiotensin II type I (AT<sub>1</sub>) receptor antagonist (IC<sub>50</sub> = 6.7 nM at hAT<sub>1</sub> receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure. Metabolite of Olmesartan medoxomil.
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| BCC1822 | ONO-AE3-208 |
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High affinity and selective EP<sub>4</sub> receptor antagonist (K<sub>i</sub> values are 1.3, 30, 790 and 2400 nM for EP<sub>4</sub>, EP<sub>3</sub>, FP and TP receptors respectively). Displays no affinity for EP<sub>1</sub>, EP<sub>2</sub>, DP or IP receptors (K<sub>i</sub> >10 <span class='symbol'>μ</span>M). Inhibits PGE<sub>2</sub>-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE<sub>2</sub> inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis and stimulates CD4<sup>+</sup> T cell proliferation in C57BL/6 mice. Also reduces metastasis of mammary tumor cells in a murine model of breast cancer. Orally active.
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| BCC1837 | Paradol |
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1. (3)-Paradol has antimicrobial activity.
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| BCC1839 | Paricalcitol |
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Analog of the active form of vitamin D2; activates the vitamin D receptor.
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| BCC1845 | Pentostatin |
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Irreversible inhibitor of adenosine deaminase (K<sub>i</sub> = 2.5 pM). Anticancer agent.
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| BCC1849 | PF-04217903 methanesulfonate |
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Highly selective, high affinity MET inhibitor (Ki = 6-7 nM against wild type c-Met). Displays >1000-fold selectivity for c-Met over a panel of 208 kinases.
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| BCC1856 | PF-670462 |
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Potent and selective casein kinase 1<span class='symbol'>ε</span> (CK1<span class='symbol'>ε</span>) and CK1<span class='symbol'>δ</span> inhibitor (IC<sub>50</sub> values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC<sub>50</sub> = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion <em>in vivo</em>.
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| BCC1857 | PF-8380 |
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Potent autotaxin inhibitor (IC50 = 2.8 nM in isolated enzyme assay; 101 nM in human whole blood). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at site of inflammation. Decreases leptin-induced MMP13 expression, in vitro. Orally available.
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