Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 249 - 256 of 9359 hot products
| Catalog No. | Product Name |
|---|---|
| BCC1860 | PI-103 Hydrochloride |
|
Inhibitor of DNA-PK, PI 3-kinase (p110<span class='symbol'>α</span>) and mTOR (IC<sub>50</sub> values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110<span class='symbol'>α</span>, mTORC1, PI 3-KC2<span class='symbol'>β</span>, p110<span class='symbol'>δ</span>, mTORC2, p110<span class='symbol'>β</span>, p110<span class='symbol'>γ</span>, ATR, ATM, PI 3-KC2<span class='symbol'>α</span> and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice <em>in vivo</em>. Induces autophagosome formation in glioma cells.
|
|
| BCC1863 | Pitolisant hydrochloride |
|
Potent and selective histamine H3 receptor inverse agonist (EC50 = 1.5 nM, Ki = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant.
|
|
| BCC1872 | PU-H71 |
|
Potent inhibitor of heat shock protein 90 (Hsp90) (IC<sub>50</sub> = 51 nM in MDA-MB-468 cells). Also inhibits cell growth in a range of breast cancer cell lines (IC<sub>50</sub> values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells respectively). Shown to inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.
|
|
| BCC1879 | R1530 |
|
Multi-kinase inhibitor. Exhibits inhibitory activity against Chk2, KDR, FGFR, Aurora A kinase and Cdk2 (IC<sub>50</sub> values are 24, 34, 50, 58 and 88 nM respectively). Also binds VEGFR-2, FGFR1 and PDGFR<span class='symbol'>β</span> (K<sub>d</sub> values are 0.015, 0.061 and 0.088 <span class='symbol'>μ</span>M respectively). Displays antiproliferative activity <em>in vitro</em>; inhibits mitosis and angiogenesis. Orally bioavailable.
|
|
| BCC1882 | Radezolid |
|
Radezolid (INN, codenamed RX-1741) is a novel oxazolidinone antibiotic agent.
|
|
| BCC1887 | RepSox |
|
Potent and selective inhibitor of the TGF-<span class='symbol'>β</span> type I receptor/ALK5 (IC<sub>50</sub> values are 4 and 23 nM for TGF-<span class='symbol'>β</span> type I receptor autophosphorylation and binding respectively). Selective for TGF-<span class='symbol'>β</span> type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC<sub>50</sub> > 16 <span class='symbol'>μ</span>M). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.
|
|
| BCC1898 | Rimonabant hydrochloride |
|
Potent and selective cannabinoid CB<sub>1</sub> receptor antagonist (K<sub>i </sub>= 1.98 nM). Also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (IC<sub>50</sub> = 48 nM). Displays no activity at CB<sub>2</sub> receptors. Reduces food intake and body weight in orally dosed non-obese Wistar rats.
|
|
| BCC1902 | RJR-2403 oxalate |
|
A neuronal nicotinic receptor agonist, showing high selectivity for the <span class='symbol'>α</span>4<span class='symbol'>β</span>2 subtype (K<sub>i</sub> values are 26 and 36000 nM for <span class='symbol'>α</span>4<span class='symbol'>β</span>2 and <span class='symbol'>α</span>7 receptors respectively). Active <em>in vivo</em>.
|
|